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- W131579049 endingPage "513" @default.
- W131579049 startingPage "502" @default.
- W131579049 abstract "Abstract We have examined platelet protein organization by treatment of intact resting or thrombin-activated platelets with two cross-linking reagents, diamide or dithiobis(succinimidyl propionate) (DTSP). Cross- linked complexes were separated by polyacrylamide gel electrophoresis in the absence of reducing agent and their composition determined after reductive cleavage and analysis in a second-dimensional gel. The most prominent cross-linked species produced by diamide treatment of of resting platelets are (A) cytoskeletal protein homopolymers, such as myosin heavy chain dimer and actin oligomers, and (B) high molecular weight material consisting of homo- or heteropolymers of cytoskeletal proteins and 230,000, 170,000, 100,000, 55,000, and 52,000 dalton proteins. DTSP treatment forms similar complexes and also cross-links membrane glycoproteins IIb and III into high molecular weight material. Thrombin activation of platelets before treatment with diamide or DTSP results in increased cross-linking of myosin and increased incorporation of several proteins, particularly myosin and glycoproteins IIb and III, into high molecular weight material. The results provide evidence for reorganization of cytoskeletal and membrane proteins during platelet function." @default.
- W131579049 created "2016-06-24" @default.
- W131579049 creator A5010639531 @default.
- W131579049 creator A5047494261 @default.
- W131579049 date "1982-03-01" @default.
- W131579049 modified "2023-10-17" @default.
- W131579049 title "Platelet protein organization: analysis by treatment with membrane- permeable cross-linking reagents" @default.
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- W131579049 doi "https://doi.org/10.1182/blood.v59.3.502.502" @default.
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