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• W13164480 endingPage "157" @default.
• W13164480 startingPage "119" @default.
• W13164480 abstract "It is an interesting time to consider the means and roles of cell adhesion in the eukaryotes. There was initial wonder at the results of Wilson’s reports of species-specific reaggregation of sponge cells (Wilson 1907), and Holtfreter’s demonstrations of cell segregation in amphibians (Holtfreter 1943). Later, there were theories about cell adhesion molecules driving histogenesis and differentiation, and speculation about how specificity could be generated (Tyler 1947; Weiss 1947; Roseman 1970). The rise of molecular methods in the 1950s and 1960s revealed that the field was extremely confusing. Various research groups could not agree on results from similar experiments, let alone on their interpretation. This confusion, in fact, stemmed from an unappreciated complexity, with the same cells adhering by different mechanisms, depending on details of cell preparation, timing, and criteria for assay endpoints. It was a great revelation that chick neural cells could adhere to each other in two different reproducible ways, depending on the concentration of Ca2+ present during tissue dissociation (Takeichi et al. 1981). In the past 10 years, we have developed frameworks and rules for understanding cell adhesion at a molecular level, aided by molecular genetics and the ability to compare gene sequences and functions. The emergence of identifiable gene families provides a frame of reference to describe the behavior of cell adhesion molecules." @default.
• W13164480 created "2016-06-24" @default.
• W13164480 creator A5028349963 @default.
• W13164480 date "1996-01-01" @default.
• W13164480 modified "2023-10-09" @default.
• W13164480 title "Cell Adhesion Proteins in the Nonvertebrate Eukaryotes" @default.
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