Matches in SemOpenAlex for { <https://semopenalex.org/work/W131931465> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W131931465 endingPage "151.9" @default.
- W131931465 startingPage "151.9" @default.
- W131931465 abstract "Abstract Mast cells play a central role in allergic inflammation and are activated through crosslinking of IgE receptors, initiating a signaling cascade resulting in production of biologically potent mediators. Signaling pathways in the regulation of specific mediators remain incompletely defined. Here, we examined the role of mitogen-activated protein kinase (MAPK) kinase 3 (MKK3) in IgE-dependent mast cell activation. In an in vivo model of passive cutaneous anaphylaxis, MKK3-deficient mice showed a deficit in late phase IgE-dependent inflammation. To characterize the mechanism of this deficiency, we cultured bone marrow-derived mast cells (BMMCs) from wild-type and MKK3 knockout (KO) mice. We found that IgE-mediated mast cell activation induced rapid MKK3 phosphorylation by 5 minutes, diminishing slowly after 6 hours. In MKK3-deficient BMMCs, phosphorylation of p38 was reduced at early and later time points. Among 40 cytokines tested using a protein array, IL-4 was the only cytokine specifically down-regulated in MKK3-deficient BMMCs. Furthermore, early growth response-1 (Egr1) bound to the promoter of IL-4 in FcϵRI-activated mast cells and Egr1 transcription factor activity was diminished from 1-6 hours in MKK3-deficient BMMCs. Thus, MKK3 is a specific regulator of IgE-induced IL-4 production likely through regulating Egr1 activity in mast cells." @default.
- W131931465 created "2016-06-24" @default.
- W131931465 creator A5029808150 @default.
- W131931465 creator A5080502857 @default.
- W131931465 date "2011-04-01" @default.
- W131931465 modified "2023-10-16" @default.
- W131931465 title "MKK3 regulates mast cell IL-4 production through Egr1. (151.9)" @default.
- W131931465 doi "https://doi.org/10.4049/jimmunol.186.supp.151.9" @default.
- W131931465 hasPublicationYear "2011" @default.
- W131931465 type Work @default.
- W131931465 sameAs 131931465 @default.
- W131931465 citedByCount "0" @default.
- W131931465 crossrefType "journal-article" @default.
- W131931465 hasAuthorship W131931465A5029808150 @default.
- W131931465 hasAuthorship W131931465A5080502857 @default.
- W131931465 hasConcept C11960822 @default.
- W131931465 hasConcept C141105273 @default.
- W131931465 hasConcept C159654299 @default.
- W131931465 hasConcept C203014093 @default.
- W131931465 hasConcept C2776914184 @default.
- W131931465 hasConcept C2778690821 @default.
- W131931465 hasConcept C2779675166 @default.
- W131931465 hasConcept C2779726688 @default.
- W131931465 hasConcept C51551487 @default.
- W131931465 hasConcept C57074206 @default.
- W131931465 hasConcept C62478195 @default.
- W131931465 hasConcept C86803240 @default.
- W131931465 hasConcept C95444343 @default.
- W131931465 hasConceptScore W131931465C11960822 @default.
- W131931465 hasConceptScore W131931465C141105273 @default.
- W131931465 hasConceptScore W131931465C159654299 @default.
- W131931465 hasConceptScore W131931465C203014093 @default.
- W131931465 hasConceptScore W131931465C2776914184 @default.
- W131931465 hasConceptScore W131931465C2778690821 @default.
- W131931465 hasConceptScore W131931465C2779675166 @default.
- W131931465 hasConceptScore W131931465C2779726688 @default.
- W131931465 hasConceptScore W131931465C51551487 @default.
- W131931465 hasConceptScore W131931465C57074206 @default.
- W131931465 hasConceptScore W131931465C62478195 @default.
- W131931465 hasConceptScore W131931465C86803240 @default.
- W131931465 hasConceptScore W131931465C95444343 @default.
- W131931465 hasIssue "1_Supplement" @default.
- W131931465 hasLocation W1319314651 @default.
- W131931465 hasOpenAccess W131931465 @default.
- W131931465 hasPrimaryLocation W1319314651 @default.
- W131931465 hasRelatedWork W188346040 @default.
- W131931465 hasRelatedWork W1977460101 @default.
- W131931465 hasRelatedWork W1982386486 @default.
- W131931465 hasRelatedWork W2004726042 @default.
- W131931465 hasRelatedWork W2016735587 @default.
- W131931465 hasRelatedWork W2017151443 @default.
- W131931465 hasRelatedWork W2032492283 @default.
- W131931465 hasRelatedWork W2038647140 @default.
- W131931465 hasRelatedWork W2099519675 @default.
- W131931465 hasRelatedWork W3028993706 @default.
- W131931465 hasVolume "186" @default.
- W131931465 isParatext "false" @default.
- W131931465 isRetracted "false" @default.
- W131931465 magId "131931465" @default.
- W131931465 workType "article" @default.