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• W131933393 abstract "In concanavalin A (Con A)-activated spleen cell (SC) cultures from normal C57BL/6 mice, the production of IL-2 peaked at 18-20 hr after initiation of cultures and declined rapidly during the next 24 hr, the decline of IL-2 activity being due, at least in part, to its utilization by the Con A-induced IL-2 receptor cells. In Con A-activated SC from BCG-infected mice, significant levels of IL-2 activity persisted in the 48-hr and 72-hr culture supernatants, a situation which seemed to be related to the depressed capacity of infected splenocytes to acquire IL-2 receptors. In cell mixing experiments, SC from infected mice actively depressed the utilization of IL-2 by Con A-activated normal SC, thus indicating that suppressor cells can down-regulate IL-2 responsiveness. These suppressor cells may belong to the B-cell lineage since they possessed the Thy-1-, sIg+ and FcR+ phenotype." @default.
• W131933393 created "2016-06-24" @default.
• W131933393 creator A5026422171 @default.
• W131933393 date "1987-11-01" @default.
• W131933393 modified "2023-10-16" @default.
• W131933393 title "A suppressor B lymphocyte inhibiting IL-2 consumption in spleen cell cultures from Mycobacterium bovis BCG-infected mice." @default.
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• W131933393 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1454133" @default.
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