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• W132023195 startingPage "1934578X1000500" @default.
• W132023195 abstract "The chemical composition of the volatile oil from berries of Croton macrostachyus Hochst. ex Del. was determined by GC and GC/MS. The oil was tested for its in vitro antileishmanial activity on two Leishmania strains, and its toxicity on the human monocytic leukemia (THP-1) cell line and erythrocytes from sheep blood. The main constituents of the oil were benzyl benzoate (51.8%), linalool (10.1%), γ-muurolene (9.3%), ( E,E)-α-farnesene (3.2%), δ-cadinene (2.8%) and α-curcumene (2.7%). The oil was effective against L. donovani and L. aethiopica promastigotes (MIC = 0.08 μL/mL and 0.16 μL/mL, respectively) and axenic amastigote stages (EC 50 = 20.00 nL/mL and 6.66 nL/mL, respectively). The CC 50 value for the oil was 10.00 nL/mL on THP-1 cells with selectivity index values of 0.5 for L. donovani and 1.5 for L. aethiopica. The median lethal concentration (LC 50 ) of the oil was 2.45 μL/mL. Thus the observed high efficacy and moderate toxicity of the volatile oil from C. macrostachyus, makes the plant a promising source of new lead compounds in the search for safe and effective antileishmanial drugs." @default.
• W132023195 created "2016-06-24" @default.
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• W132023195 date "2010-06-01" @default.
• W132023195 modified "2023-09-28" @default.
• W132023195 title "Constituents, Antileishmanial Activity and Toxicity Profile of Volatile Oil from Berries of <i>Croton macrostachyus</i>" @default.
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• W132023195 doi "https://doi.org/10.1177/1934578x1000500635" @default.
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