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- W132052208 abstract "Widespread inherent or acquired resistance to cytotoxic drugs is a major limitation to chemotherapy. There are many mechanisms that contribute to such resistance. In neuroblastomas there is evidence that acquired drug resistance may be associated with altered response to growth factor signals. The ubiquitous mitogen-activated protein kinase (MAPk) cascade, which transmits growth factor signals from the cell membrane to the nucleus, provides a principal mechanism for regulation of cell cycle progression and proliferation. We have shown that there is a relationship between acquired drug resistance in human neuroblastoma cells to doxorubicin, a topoisomerase-2 inhibitor, and to MDL-28842, an inhibitor of S-adenosylhomocysteine hydrolase, and reductions in the activation and nuclear translocation of MAPk." @default.
- W132052208 created "2016-06-24" @default.
- W132052208 creator A5071945560 @default.
- W132052208 date "2003-11-18" @default.
- W132052208 modified "2023-09-27" @default.
- W132052208 title "Mitogen-Activated Protein Kinase Signaling in Drug-Resistant Neuroblastoma Cells" @default.
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- W132052208 doi "https://doi.org/10.1385/1-59259-356-9:71" @default.
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