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- W132506586 abstract "This chapter focuses on human natural killer (NK) cell function in chronic diseases. It presents recent studies showing defects in the IFN–NK system in patients with chronic diseases, explains the observed defects, and discusses their significance to the pathogenesis of these diseases. In a study described in the chapter, NK of peripheral blood mononuclear cells (PBMC) were tested against K562 targets using a short term (4 or 5 h) conventional 51Cr-release cytotoxicity assay. It was observed that approximately 30% of patients with multiple sclerosis (MS) and 40% with systemic lupus erythematosus (SLE) exhibit NK significantly below that of normal donors, that is, outside the 95% confidence limits for the normal group mean. In contrast, patients with rheumatoid arthritis (RA) do not differ significantly from the normal population. In addition to endogenous NK, this study determined the response of patients' and normal donors' NK to augmentation by IFN and IFN inducers. While the majority of MS patients were augmented with IFN in vitro, their levels of augmented NK rarely reached those of normal donors, and the group mean NK was significantly reduced." @default.
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- W132506586 date "1982-01-01" @default.
- W132506586 modified "2023-10-16" @default.
- W132506586 title "STUDIES OF HUMAN NK CELL FUNCTION IN CHRONIC DISEASES" @default.
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- W132506586 doi "https://doi.org/10.1016/b978-0-12-341360-4.50183-9" @default.
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