Matches in SemOpenAlex for { <https://semopenalex.org/work/W132652181> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W132652181 endingPage "291" @default.
- W132652181 startingPage "281" @default.
- W132652181 abstract "Dipeptidyl Peptidase IV (DP IV; EC 3.4.14.5; CD26) is a membrane bound ectopeptidase found on numerous cell types including vascular endothelium and certain functional leukocyte subsets. A soluble form of the enzyme, lacking a short transmembrane sequence, can also be found circulating in the plasma. With a substrate specificity favouring oligopeptides with a penultimate prolyl-, analyl-, or serylresidue at the Nterminus, DP IV rapidly cleaves the N-terminal dipeptide from a number of metabolic hormones and neuroendocrine factors including (in order of catalytic efficiency) NPY, PYY, and the gluco-regulatory peptides glucagonlike peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon. Released post-prandially from the intestinal mucosa, GIP and GLP-1 are responsible for >50% of meal-stimulated insulin release. Their potent insulinotropic actions are the result of direct interaction of these “incretin” hormones with their respective G-protein coupled receptors on the surface of the pancreatic Like all members of the glucagon/secretin superfamily" @default.
- W132652181 created "2016-06-24" @default.
- W132652181 creator A5001127178 @default.
- W132652181 creator A5012013902 @default.
- W132652181 creator A5013450317 @default.
- W132652181 creator A5014579890 @default.
- W132652181 creator A5039760583 @default.
- W132652181 creator A5048701474 @default.
- W132652181 date "2004-01-01" @default.
- W132652181 modified "2023-10-16" @default.
- W132652181 title "Dipeptidyl Peptidase IV Inhibition in Animal Models of Diabetes" @default.
- W132652181 cites W1554419393 @default.
- W132652181 cites W1966418185 @default.
- W132652181 cites W2000465889 @default.
- W132652181 cites W2031468509 @default.
- W132652181 cites W2032541516 @default.
- W132652181 cites W2040457938 @default.
- W132652181 cites W2068361325 @default.
- W132652181 cites W2076880341 @default.
- W132652181 cites W2106339546 @default.
- W132652181 cites W2112021812 @default.
- W132652181 cites W2126720228 @default.
- W132652181 cites W2134534032 @default.
- W132652181 cites W2141264129 @default.
- W132652181 cites W2142081640 @default.
- W132652181 cites W2145140318 @default.
- W132652181 cites W2146232529 @default.
- W132652181 cites W2161075296 @default.
- W132652181 cites W2162768091 @default.
- W132652181 cites W4230178491 @default.
- W132652181 cites W4235365453 @default.
- W132652181 cites W4242583868 @default.
- W132652181 doi "https://doi.org/10.1007/0-306-47920-6_34" @default.
- W132652181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12675250" @default.
- W132652181 hasPublicationYear "2004" @default.
- W132652181 type Work @default.
- W132652181 sameAs 132652181 @default.
- W132652181 citedByCount "17" @default.
- W132652181 countsByYear W1326521812012 @default.
- W132652181 countsByYear W1326521812013 @default.
- W132652181 countsByYear W1326521812014 @default.
- W132652181 countsByYear W1326521812016 @default.
- W132652181 countsByYear W1326521812022 @default.
- W132652181 crossrefType "book-chapter" @default.
- W132652181 hasAuthorship W132652181A5001127178 @default.
- W132652181 hasAuthorship W132652181A5012013902 @default.
- W132652181 hasAuthorship W132652181A5013450317 @default.
- W132652181 hasAuthorship W132652181A5014579890 @default.
- W132652181 hasAuthorship W132652181A5039760583 @default.
- W132652181 hasAuthorship W132652181A5048701474 @default.
- W132652181 hasConcept C134018914 @default.
- W132652181 hasConcept C156490143 @default.
- W132652181 hasConcept C181199279 @default.
- W132652181 hasConcept C185592680 @default.
- W132652181 hasConcept C2777180221 @default.
- W132652181 hasConcept C2781469919 @default.
- W132652181 hasConcept C55493867 @default.
- W132652181 hasConcept C555293320 @default.
- W132652181 hasConcept C71924100 @default.
- W132652181 hasConcept C98274493 @default.
- W132652181 hasConceptScore W132652181C134018914 @default.
- W132652181 hasConceptScore W132652181C156490143 @default.
- W132652181 hasConceptScore W132652181C181199279 @default.
- W132652181 hasConceptScore W132652181C185592680 @default.
- W132652181 hasConceptScore W132652181C2777180221 @default.
- W132652181 hasConceptScore W132652181C2781469919 @default.
- W132652181 hasConceptScore W132652181C55493867 @default.
- W132652181 hasConceptScore W132652181C555293320 @default.
- W132652181 hasConceptScore W132652181C71924100 @default.
- W132652181 hasConceptScore W132652181C98274493 @default.
- W132652181 hasLocation W1326521811 @default.
- W132652181 hasLocation W1326521812 @default.
- W132652181 hasOpenAccess W132652181 @default.
- W132652181 hasPrimaryLocation W1326521811 @default.
- W132652181 hasRelatedWork W1563993585 @default.
- W132652181 hasRelatedWork W2022733261 @default.
- W132652181 hasRelatedWork W2028525884 @default.
- W132652181 hasRelatedWork W2054357573 @default.
- W132652181 hasRelatedWork W2070538101 @default.
- W132652181 hasRelatedWork W2084702739 @default.
- W132652181 hasRelatedWork W2095222923 @default.
- W132652181 hasRelatedWork W2264366323 @default.
- W132652181 hasRelatedWork W2912944305 @default.
- W132652181 hasRelatedWork W4248632178 @default.
- W132652181 isParatext "false" @default.
- W132652181 isRetracted "false" @default.
- W132652181 magId "132652181" @default.
- W132652181 workType "book-chapter" @default.