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• W132653936 abstract "OF DISSERTATION MOLECULAR AND CELLULAR CHARACTERIZATION OF THE DOPAMINE NEURON STIMULATING PEPTIDES Parkinson’s disease, the second most common neurodegenerative disease, is characterized by the loss of dopaminergic neurons within the substantia nigra. Currently, the treatments available for PD are symptomatic treatments that do not stop the progression of the disease. Trophic molecules, such as glial cell-line derived neurotrophic factor (GDNF), have been evaluated as potential therapeutic molecules that could stop the loss of neurons and potentially restore some of the neurons that have already been lost. However, these trophic molecules are large making them difficult to produce and delivery. Here we characterize three peptides (DNSP-5, DNSP-11, and DNSP-17) to determine it they are stable and offer protective effects similar to GNDF allowing them to be potential therapeutic molecules. The data presented here involves the evaluation of the molecular and cellular mechanism of DNSP-5, DNSP-11, and DNSP-17, which are derived from prosequence of GDNF. Initial studies were carried out to evaluate the physical characteristics of these three peptides to determine their viability as potential therapeutic molecules. The structure and stability of these peptides were evaluated. Based on the data it was determined that the three peptides do not interact in vitro, allowing for further individual evaluations of the peptides. It was also determined that the peptides were stable when stored at both -80°C and 37°C for one month, allowing them to both potentially be stored during treatment. Cell culture assays and proteomic profiling were utilized to determine binding partners and potential mechanisms through which DNSP-11 may be able to mediate apoptosis. It was determined that DNSP-11 was able to interact with a variety of binding partners that are involved in metabolism. These studies have aided in the understanding of neurotrophic factor prosequence function, but will also serve as a starting point for the development of novel trophic factors for PD treatment. Finally, the interaction between DNSP-11 and GAPDH was evaluated as a potential anti-apoptotic mechanism. GAPDH has previously shown to play a role in mediating apoptotic pathways. It was hypothesized that the observed interaction between DNSP-11 and GAPDH could mediate that role of GAPDH in apoptosis and afford DNSP-11 its observed anti-apoptotic effects. It was observed that while DNSP-11’s interaction with GAPDH may play a role in its anti-apoptotic effects, it does not appear to be the only mechanism involved. Based on this data, it is likely that the other metabolic binding partners play a role in DNSP-11’s anti-apoptotic mechanisms and therefore, these interactions should be further evaluated." @default.
• W132653936 created "2016-06-24" @default.
• W132653936 creator A5001384716 @default.
• W132653936 date "2013-01-01" @default.
• W132653936 modified "2023-09-27" @default.
• W132653936 title "Molecular and Cellular Characterization of Dopamine Neuron Stimulating Peptides" @default.
• W132653936 cites W1033087388 @default.
• W132653936 cites W110116697 @default.
• W132653936 cites W11847823 @default.
• W132653936 cites W141636555 @default.
• W132653936 cites W1484568938 @default.
• W132653936 cites W1501353578 @default.
• W132653936 cites W1504584187 @default.
• W132653936 cites W1507318381 @default.
• W132653936 cites W1527671059 @default.
• W132653936 cites W1550876205 @default.
• W132653936 cites W1577130619 @default.
• W132653936 cites W1583740060 @default.
• W132653936 cites W1590012920 @default.
• W132653936 cites W1638542732 @default.
• W132653936 cites W1821174618 @default.
• W132653936 cites W1830728982 @default.
• W132653936 cites W1900535849 @default.
• W132653936 cites W1902058987 @default.
• W132653936 cites W1941281848 @default.
• W132653936 cites W1965986364 @default.
• W132653936 cites W1966432826 @default.
• W132653936 cites W1968547636 @default.
• W132653936 cites W1969199506 @default.
• W132653936 cites W1969270873 @default.
• W132653936 cites W1969349734 @default.
• W132653936 cites W1969479602 @default.
• W132653936 cites W1969950937 @default.
• W132653936 cites W1970416276 @default.
• W132653936 cites W1971258758 @default.
• W132653936 cites W1971389338 @default.
• W132653936 cites W1972229214 @default.
• W132653936 cites W1973174174 @default.
• W132653936 cites W1973304468 @default.
• W132653936 cites W1975637203 @default.
• W132653936 cites W1977454957 @default.
• W132653936 cites W1977567629 @default.
• W132653936 cites W1979848970 @default.
• W132653936 cites W1983265620 @default.
• W132653936 cites W1984726522 @default.
• W132653936 cites W1984800697 @default.
• W132653936 cites W1986625112 @default.
• W132653936 cites W1988111175 @default.
• W132653936 cites W1988457275 @default.
• W132653936 cites W1988791308 @default.
• W132653936 cites W1989381407 @default.
• W132653936 cites W1989386072 @default.
• W132653936 cites W1991208841 @default.
• W132653936 cites W1991231955 @default.
• W132653936 cites W1991600275 @default.
• W132653936 cites W1992181345 @default.
• W132653936 cites W1992466885 @default.
• W132653936 cites W199354732 @default.
• W132653936 cites W1993605428 @default.
• W132653936 cites W1993806602 @default.
• W132653936 cites W1994452959 @default.
• W132653936 cites W1995246942 @default.
• W132653936 cites W1995262469 @default.
• W132653936 cites W1996971085 @default.
• W132653936 cites W1997597731 @default.
• W132653936 cites W1997631088 @default.
• W132653936 cites W1998885927 @default.
• W132653936 cites W1999127620 @default.
• W132653936 cites W2002358648 @default.
• W132653936 cites W2002506451 @default.
• W132653936 cites W2003861040 @default.
• W132653936 cites W2004434463 @default.
• W132653936 cites W2007881147 @default.
• W132653936 cites W2009835677 @default.
• W132653936 cites W2013331421 @default.
• W132653936 cites W2014078232 @default.
• W132653936 cites W2015167814 @default.
• W132653936 cites W2017530051 @default.
• W132653936 cites W2019050557 @default.
• W132653936 cites W2019695510 @default.
• W132653936 cites W2020244870 @default.
• W132653936 cites W2020390006 @default.
• W132653936 cites W2021083387 @default.
• W132653936 cites W2022034337 @default.
• W132653936 cites W2022863957 @default.
• W132653936 cites W2023285758 @default.
• W132653936 cites W2023505129 @default.
• W132653936 cites W2024880736 @default.
• W132653936 cites W2027988197 @default.
• W132653936 cites W2028093783 @default.
• W132653936 cites W2028607742 @default.
• W132653936 cites W2029107495 @default.
• W132653936 cites W2030653104 @default.
• W132653936 cites W2031031932 @default.
• W132653936 cites W2031345305 @default.
• W132653936 cites W2032554568 @default.
• W132653936 cites W2033887763 @default.
• W132653936 cites W2033985997 @default.
• W132653936 cites W2034067256 @default.
• W132653936 cites W2034110115 @default.

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