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- W132768498 abstract "Translational medicine has opened the gateway to the era of personalized medicine. No longer a “one size fits all” approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. Although oncology still functions within broad disease categories, the future will see an increasing shift to treatment based on the characteristics of an individual’s tumor type. Interestingly, one of the first targeted therapies, all-trans retinoic acid in acute promyelocytic leukemia, was first demonstrated at the bedside with a subsequent return to the bench to elucidate its underlying basis. This was a translocation resulting in disruption of the retinoic acid receptor-α gene. Since then, a rigorous translational approach has led to other success stories, such as imatinib and dasatinib in Philadelphia-positive leukemias. With the discovery of novel biologic agents, future challenges lie in the investigation of optimal combinations and the identification of biomarkers that can provide both predictive and prognostic information. Genomics, proteomics, and the application of mathematical modeling are leading the way to biomarker discovery. Further elucidation of the cancer “stem cell hypothesis” will lead to treatment with combinations of agents used to target both early epigenetic mechanisms and downstream molecular events. With targeted agents that demonstrate increased efficacy and decreased toxicity, we are now approaching cancer as a chronic disease model. Personalized medicine, with a “bench to bedside and back” paradigm is poised to permanently alter the landscape for cancer management." @default.
- W132768498 created "2016-06-24" @default.
- W132768498 creator A5036211173 @default.
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- W132768498 date "2008-03-06" @default.
- W132768498 modified "2023-09-27" @default.
- W132768498 title "Perspectives: Bench to Bedside and Back" @default.
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- W132768498 doi "https://doi.org/10.1007/978-1-60327-424-1_1" @default.
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