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- W13285587 abstract "The pituitary glycoprotein hormone known as follicle-stimulating hormone (FSH) plays a fundamental role in folliculogenesis and spermatogenesis in mammals. Precise regulation of its synthesis and secretion is therefore vital to normal reproductive function, particularly in females. Several endocrine, paracrine, and autocrine factors within the hypothalamo-pituitary-gonadal axis have been identified as important regulators of FSH, including gonadotropin-releasing hormone (GnRH), inhibin, activin, follistatin, and the sex-steroid hormones. Over the past several years, a variety of genetic loss- and gain-of-function models have been created in mice using gene targeting and transgenic technologies. This chapter reviews the contributions of a variety of these models to our understanding of FSH synthesis, secretion, and function. Many of the models confirm results from years of physiological experimentation, but new insights into FSH regulation and action have emerged as a result of these advances in molecular genetics. Continued development of these models, along with the use of novel in vitro model systems, will significantly advance our understanding of FSH biology." @default.
- W13285587 created "2016-06-24" @default.
- W13285587 creator A5015669502 @default.
- W13285587 creator A5030949220 @default.
- W13285587 date "2001-01-01" @default.
- W13285587 modified "2023-09-23" @default.
- W13285587 title "Genetic Approaches to the Study of Pituitary Follicle-Stimulating Hormone Regulation" @default.
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- W13285587 doi "https://doi.org/10.1007/978-1-59259-102-2_14" @default.
- W13285587 hasPublicationYear "2001" @default.
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