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- W132877293 endingPage "95" @default.
- W132877293 startingPage "84" @default.
- W132877293 abstract "Natural killer (NK) cells are a subpopulation of lymphocytes distinct from both T and B cells (Lanier et al., 1986d). In man, NK cells are identified as lymphocytes with the antigenic phenotype membrane CD3ε −, CD16+ and/or CD56+ (Lanier et al., 1986d). In the mouse, NK cells are membrane CD3ε −, and in some strains NK1.1+. Unlike T lymphocytes, NK cells do not rearrange T-cell receptor (TCR) α, β, γ, or δ genes (Lanier et al., 1986a, 1986b; Tutt et al., 1986, 1987; Loh et al., 1988). NK cell function and maturation, moreover, is normal in scid mice (Hackett et al., 1986; Tutt et al., 1987), in which the development of T and B lymphocytes is arrested due to a defect in the process necessary for rearrangement of immunoglobulin and T-cell antigen receptor (Bosma et al., 1983; Schuler et al., 1986; Bosma et al., 1991). These observations suggest that NK cells constitute a distinct lineage of lymphocytes, and they indicate that the recombinase mechanisms present in B and T lymphocytes are not required for NK development or function. A relationship between T and NK progenitor cells prior to TCR rearrangement is nonetheless quite possible, given the remarkable similarities in the functional and antigenic phenotypes of these lymphocytes." @default.
- W132877293 created "2016-06-24" @default.
- W132877293 creator A5000763253 @default.
- W132877293 creator A5090705084 @default.
- W132877293 date "1993-01-01" @default.
- W132877293 modified "2023-10-17" @default.
- W132877293 title "Triggering Structures on NK Cells" @default.
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