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- W133018429 abstract "11 Objectives: This study examined the utility of two cardiac 123-I-MIBG uptake ratios for defining risk for potentially life-threatening ventricular arrhythmia in heart failure (HF) patients. Methods: 195 HF pts (156 M, 39F; 50±10 yrs; NHYA Class II:132,III:59, IV:4; 118 dilated, 77 ischemic; mean LVEF: 33±13%) imaged from 1999-2002 were included. Using heart (H) and mediatinum (M) region count data from delayed (3-5 hour) anterior planar 123I-MIBG images. H/M average (av) and H/M maximum (max) ratios were calculated. These were compared against occurence of arrhythmic (sustained ventricular arrhythmia, appropriate ICD discharge, sudden cardiac death (SDC) and non-arrhythmic (cardiac transplant; non-SCD cardiac death) cardiac events (CE) during 24-month follow-up. Results: There were 36 CEs (18%): 9 deaths (5 SCD), 22 transplants, 5 other arrhythmic events. Mean H/Mav : CE:1.65±0.3; no CE:2.09±0.56 (p 2.2, H/Mmax>4.62) uptake. The very low risk cohort was larger using H/Mmax (n=75 (38%)) than H/Mav (n=61 (31%)). Conclusions: 123I-MIBG imaging can identify patients with relatively high and very low 2-year arrhythmic event risk. H/Mmax appears to provide a modest advantage over H/Mav for identifying the very low risk cohort." @default.
- W133018429 created "2016-06-24" @default.
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- W133018429 date "2007-05-01" @default.
- W133018429 modified "2023-09-23" @default.
- W133018429 title "Utility of I-123-MIBG scintigraphy in subjects with heart failure for assessment of risk for potentially life-threatening ventricular arrhythmia" @default.
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