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- W133028776 abstract "This chapter discusses the effect of albumin on the size-limiting structures determining transcapillary exchange. Removal of plasma proteins from the perfusate causes an increased permeability and decreased selectivity of the walls of the continuous capillaries of mammalian muscle and frog mesentery. In individually perfused capillaries of frog mesentery, it has been shown that a fivefold increase in the hydraulic conductivity of the capillary wall is reversed by the addition of albumin, γ globulin, or hemoglobin to the capillary perfusate. In a study described in the chapter, the ultrastructure of capillaries perfused without albumin was examined and no conspicuous abnormalities were found. It was shown that albumin combines reversibly with some electron-lucent component of the capillary wall to increase the frictional resistance of transcapillary channels to water and hydrophilic solutes. The hypothesis that albumen is a component of a size limiting fibrous network within transcapillary channels conforms to the experimental data obtained from the present study. The physical and chemical properties of the fibrous network must be considered in future attempts to correlate the structure and function of the capillary wall." @default.
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- W133028776 date "1981-01-01" @default.
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- W133028776 title "THE EFFECT OF ALBUMIN ON THE SIZE-LIMITING STRUCTURES DETERMINING TRANSCAPILLARY EXCHANGE" @default.
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- W133028776 doi "https://doi.org/10.1016/b978-0-08-026819-4.50023-4" @default.
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