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- W133043500 abstract "A novel procedure for detecting linkage disequilibrium is proposed which has only one degree of freedom irrespective of the number of alleles at the marker locus under consideration. In this test, all marker allele frequencies are determined as a function of the true marker allele frequencies, the recombination fraction between marker and disease, and the number of generations since an initial disease mutation was introduced into the population. Under the restrictive assumption of one initial founder mutation occuring in the population under study, it is possible to predict the marker allele frequency in the case sample as follows: p{sub n}=p{sub n{minus}1}(1-{theta}) + q{sub n{minus}1}{theta}, where p{sub n} is the frequency in the case sample of the allele in generation n, and q{sub n} is the frequency of said marker allele in the control sample. Then a test of linkage disequilibrium can be parametrized as a function of {theta} using a {open_quotes}LOD{close_quotes} score statistic as log{sub 10}[L({theta})/L({theta}=0.5)], where the allele frequencies in generation 0, and the number of generations since introduction of the allele to the population are treated as nuisance parameters and estimated separately in numerator and denominator, thus leaving us with a test statistic on one df, irrespective ofmore » the number of alleles at the marker locus. While the assumptions are often not reasonable, violations of said assumptions will simply have the effect of making the test less powerful. Still, the test is consistently more powerful than the standard 2 x n table chi-square test of association for multi-allelic marker systems. Multiple founders, non-zero mutation rates, and an extension to multipoint association tests are under development.« less" @default.
- W133043500 created "2016-06-24" @default.
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- W133043500 date "1994-09-01" @default.
- W133043500 modified "2023-09-26" @default.
- W133043500 title "A powerful one degree of freedom approach to mapping genes with linkage disequilibrium" @default.
- W133043500 hasPublicationYear "1994" @default.
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