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• W133060954 abstract "Research Article15 July 1996free access Activation of the IL-2 gene promoter by HTLV-I tax involves induction of NF-AT complexes bound to the CD28-responsive element. L. Good L. Good Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, PA 17033, USA. Search for more papers by this author S. B. Maggirwar S. B. Maggirwar Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, PA 17033, USA. Search for more papers by this author S. C. Sun S. C. Sun Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, PA 17033, USA. Search for more papers by this author L. Good L. Good Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, PA 17033, USA. Search for more papers by this author S. B. Maggirwar S. B. Maggirwar Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, PA 17033, USA. Search for more papers by this author S. C. Sun S. C. Sun Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, PA 17033, USA. Search for more papers by this author Author Information L. Good1, S. B. Maggirwar1 and S. C. Sun1 1Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, PA 17033, USA. The EMBO Journal (1996)15:3744-3750https://doi.org/10.1002/j.1460-2075.1996.tb00744.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The tax gene product of the type I human T-cell leukemia virus (HTLV-I) is a potent transcriptional activator of various growth-related cellular genes, including that encoding interleukin-2 (IL-2). Tax activation of many of these target genes appears to be mediated by the NF-kappa B/Rel and CREB/ATF family of cellular transcription factors. However, the mechanism by which Tax transactivates the IL-2 gene remains unclear. In the present study, we demonstrate that neither NF-kappa B/Rel nor CREB/ATF is sufficient for Tax-mediated activation of the IL-2 promoter. Two novel nuclear protein complexes are induced by Tax and specifically bind to an IL-2 gene enhancer, the CD28-responsive element (CD28RE). Immunobiochemical analyses suggest that these DNA binding complexes contain at least two members of the nuclear factor of activated T cells, NF-ATp and NF-ATc. However, the CD28 binding NF-AT complexes do not contain Jun and Fos family proteins that have been proposed to serve as NF-AT partners in the activation of the IL-2 NF-AT motif. Transient transfection studies demonstrate that the in vivo expressed NF-ATp binds to the CD28RE probe and enhances Tax-mediated activation of this critical IL-2 enhancer. We demonstrate further that binding of NF-AT to CD28RE is critical for Tax activation of the IL-2 promoter. Together, these results suggest a novel mechanism of Tax-mediated activation of the IL-2 gene, which involves the induction of NF-AT-containing CD28RE binding complexes. Previous ArticleNext Article Volume 15Issue 141 July 1996In this issue RelatedDetailsLoading ..." @default.
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• W133060954 title "Activation of the IL-2 gene promoter by HTLV-I tax involves induction of NF-AT complexes bound to the CD28-responsive element." @default.
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• W133060954 doi "https://doi.org/10.1002/j.1460-2075.1996.tb00744.x" @default.
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