Matches in SemOpenAlex for { <https://semopenalex.org/work/W133088325> ?p ?o ?g. }
- W133088325 endingPage "80" @default.
- W133088325 startingPage "67" @default.
- W133088325 abstract "The parasitic mushroom Laetiporus sulphureus produces a family of lectins (LSL's) sharing 80-90% sequence identity that possesses a low but significant sequence similarity to the bacterial pore-forming toxins mosquitocidal toxin Mtx-2 from Bacillus sphaericus and a toxin from Clostridium septicum. The crystal structure of one member of the L. sulphureus lectins family (LSLa) reveals unexpected structural similarities to the 1-pore-forming toxins from the aerolysin family, namely, aerolysin from the Gram-negative bacterium Aeromonas hydrophila, epsilon-toxin from Clostridium perfringens and parasporin from B. thuringiensis. This similarity presumably indicates that the hemolytic activity of LSLa proceeds through a molecular mechanism that involves the formation of oligomeric transmembrane beta-barrels. Comparison of the crystal structures of the above mentioned proteins reveals common pore-forming modules, which are then distributed both in bacteria and fungi. Currently, it can be stated that the above three dimensional structures have been key in revealing structural similarities that were elusive at the sequence level. A potential corollary from this is that structural studies aimed at determining high resolution structures of aerolysin-like pore-forming toxins, whose biological activity involves large conformational changes, are mandatory to define protein domains or structural motifs with membrane-binding properties." @default.
- W133088325 created "2016-06-24" @default.
- W133088325 creator A5007901263 @default.
- W133088325 creator A5033039943 @default.
- W133088325 creator A5073268079 @default.
- W133088325 creator A5080209601 @default.
- W133088325 date "2010-01-01" @default.
- W133088325 modified "2023-10-03" @default.
- W133088325 title "Laetiporus sulphureus Lectin and Aerolysin Protein Family" @default.
- W133088325 cites W1542001620 @default.
- W133088325 cites W1559574137 @default.
- W133088325 cites W1926568554 @default.
- W133088325 cites W1932669647 @default.
- W133088325 cites W1972209346 @default.
- W133088325 cites W1979687582 @default.
- W133088325 cites W1982548986 @default.
- W133088325 cites W1984492103 @default.
- W133088325 cites W1997136952 @default.
- W133088325 cites W2001276190 @default.
- W133088325 cites W2010610528 @default.
- W133088325 cites W2014307378 @default.
- W133088325 cites W2015245307 @default.
- W133088325 cites W2016055700 @default.
- W133088325 cites W2022058405 @default.
- W133088325 cites W2024895112 @default.
- W133088325 cites W2030683115 @default.
- W133088325 cites W2039617999 @default.
- W133088325 cites W2046535373 @default.
- W133088325 cites W2055378374 @default.
- W133088325 cites W2055997032 @default.
- W133088325 cites W2059438651 @default.
- W133088325 cites W2062486325 @default.
- W133088325 cites W2065323418 @default.
- W133088325 cites W2065663657 @default.
- W133088325 cites W2067021503 @default.
- W133088325 cites W2072183656 @default.
- W133088325 cites W2072219110 @default.
- W133088325 cites W2075323026 @default.
- W133088325 cites W2076111323 @default.
- W133088325 cites W2078302553 @default.
- W133088325 cites W2080305580 @default.
- W133088325 cites W2085493064 @default.
- W133088325 cites W2086047770 @default.
- W133088325 cites W2086193113 @default.
- W133088325 cites W2086501160 @default.
- W133088325 cites W2090821297 @default.
- W133088325 cites W2094095233 @default.
- W133088325 cites W2100185604 @default.
- W133088325 cites W2101009025 @default.
- W133088325 cites W2102135397 @default.
- W133088325 cites W2102434695 @default.
- W133088325 cites W2104215220 @default.
- W133088325 cites W2104267463 @default.
- W133088325 cites W2114283841 @default.
- W133088325 cites W2121615663 @default.
- W133088325 cites W2139406125 @default.
- W133088325 cites W2150086358 @default.
- W133088325 cites W2153425238 @default.
- W133088325 cites W2159542619 @default.
- W133088325 cites W2168469272 @default.
- W133088325 cites W2172151424 @default.
- W133088325 cites W4230785217 @default.
- W133088325 cites W4239828048 @default.
- W133088325 doi "https://doi.org/10.1007/978-1-4419-6327-7_6" @default.
- W133088325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20687481" @default.
- W133088325 hasPublicationYear "2010" @default.
- W133088325 type Work @default.
- W133088325 sameAs 133088325 @default.
- W133088325 citedByCount "28" @default.
- W133088325 countsByYear W1330883252012 @default.
- W133088325 countsByYear W1330883252013 @default.
- W133088325 countsByYear W1330883252015 @default.
- W133088325 countsByYear W1330883252016 @default.
- W133088325 countsByYear W1330883252017 @default.
- W133088325 countsByYear W1330883252018 @default.
- W133088325 countsByYear W1330883252019 @default.
- W133088325 countsByYear W1330883252020 @default.
- W133088325 countsByYear W1330883252021 @default.
- W133088325 countsByYear W1330883252022 @default.
- W133088325 countsByYear W1330883252023 @default.
- W133088325 crossrefType "book-chapter" @default.
- W133088325 hasAuthorship W133088325A5007901263 @default.
- W133088325 hasAuthorship W133088325A5033039943 @default.
- W133088325 hasAuthorship W133088325A5073268079 @default.
- W133088325 hasAuthorship W133088325A5080209601 @default.
- W133088325 hasConcept C104317684 @default.
- W133088325 hasConcept C174319367 @default.
- W133088325 hasConcept C174921431 @default.
- W133088325 hasConcept C2777367657 @default.
- W133088325 hasConcept C2779441561 @default.
- W133088325 hasConcept C2780758401 @default.
- W133088325 hasConcept C523546767 @default.
- W133088325 hasConcept C54355233 @default.
- W133088325 hasConcept C547475151 @default.
- W133088325 hasConcept C55493867 @default.
- W133088325 hasConcept C66999527 @default.
- W133088325 hasConcept C86803240 @default.
- W133088325 hasConcept C89423630 @default.