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- W133119128 abstract "The beneficial acute hemodynamic effects of vasodilators in patients with congestive heart failure are well established (1, 2). The use of vasodilators in long-term management of chronic heart failure is being intensively evaluated, and nitrates are among the earliest and most extensively studied agents employed for chronic afterload reduction (3–7). Loss of hemodynamic efficacy of some vasodilators has been demonstrated in patients with heart failure, while tolerance to nitrates as antianginal agents has been suggested (8–10). Furthermore, the venodilating effect of nitrates may become blunted with time (11). It is therefore extremely important to establish long-term hemodynamic efficacy of nitrates if they are to be important in the treatment of chronic congestive heart failure." @default.
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- W133119128 date "1983-01-01" @default.
- W133119128 modified "2023-09-27" @default.
- W133119128 title "Lack of Tolerance Development to the Hemodynamic Effects of Nitrates in Patients with Chronic Congestive Heart Failure" @default.
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- W133119128 doi "https://doi.org/10.1007/978-3-642-85323-4_4" @default.
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