Matches in SemOpenAlex for { <https://semopenalex.org/work/W133243695> ?p ?o ?g. }
- W133243695 endingPage "1252" @default.
- W133243695 startingPage "1219" @default.
- W133243695 abstract "A hallmark of gliomas is the ability of individual tumor cells to infiltrate the neural tissue and extend beyond the visible borders of the tumor. Current treatments fail to remove these invasive cells, which almost invariably lead to tumor dissemination and therapy failure in the long term. The composition and properties of the extracellular matrix (ECM) in the adult central nervous system are notoriously inhibitory to cell motility and axonal extension. However, glioma cells are uniquely able to remodel this microenvironment by degradation of the neural ECM and production of a novel matrix that contains neural-specific and mesenchymal components. Structural signals from the ECM and soluble factors from the surrounding non-neoplastic cells regulate the molecular and cellular mechanisms of invasion, which include matrix remodeling, cytoskeletal reorganization, and phenotype transition from highly proliferative to migratory. Specific strategies against invading glioma cells are in their infancy due to the paucity of appropriate targets and the difficulty of predicting the effects of targeting this highly plastic cell population in vivo. Identification of the key molecular mechanisms necessary for cell invasion and the major switches that regulate the inter-conversion of migratory and proliferative phenotypes will provide a wealth of novel targets to direct therapies against brain tumor progression and improve long-term patient survival." @default.
- W133243695 created "2016-06-24" @default.
- W133243695 creator A5008836248 @default.
- W133243695 creator A5076488286 @default.
- W133243695 date "2009-01-01" @default.
- W133243695 modified "2023-10-18" @default.
- W133243695 title "Glioma Invasion: Mechanisms and Therapeutic Challenges" @default.
- W133243695 cites W1498287170 @default.
- W133243695 cites W1502546829 @default.
- W133243695 cites W1534818109 @default.
- W133243695 cites W1576158911 @default.
- W133243695 cites W1626846833 @default.
- W133243695 cites W1660686599 @default.
- W133243695 cites W178341381 @default.
- W133243695 cites W1967880385 @default.
- W133243695 cites W1968054914 @default.
- W133243695 cites W1970476447 @default.
- W133243695 cites W1971247842 @default.
- W133243695 cites W1974300394 @default.
- W133243695 cites W1974815300 @default.
- W133243695 cites W1975219368 @default.
- W133243695 cites W1975454216 @default.
- W133243695 cites W1977937744 @default.
- W133243695 cites W1979543876 @default.
- W133243695 cites W1982130586 @default.
- W133243695 cites W1984166243 @default.
- W133243695 cites W1984417662 @default.
- W133243695 cites W1987239717 @default.
- W133243695 cites W1987452783 @default.
- W133243695 cites W1987606222 @default.
- W133243695 cites W1988692970 @default.
- W133243695 cites W1990156603 @default.
- W133243695 cites W1990837582 @default.
- W133243695 cites W1992478375 @default.
- W133243695 cites W1994567037 @default.
- W133243695 cites W1994859763 @default.
- W133243695 cites W1996679013 @default.
- W133243695 cites W1997100416 @default.
- W133243695 cites W1997695178 @default.
- W133243695 cites W1997773537 @default.
- W133243695 cites W1999641808 @default.
- W133243695 cites W2002991083 @default.
- W133243695 cites W2003500892 @default.
- W133243695 cites W2004921564 @default.
- W133243695 cites W2007910632 @default.
- W133243695 cites W2009275174 @default.
- W133243695 cites W2009385362 @default.
- W133243695 cites W2010675923 @default.
- W133243695 cites W2011394735 @default.
- W133243695 cites W2012521900 @default.
- W133243695 cites W2018093166 @default.
- W133243695 cites W2019746097 @default.
- W133243695 cites W2020820485 @default.
- W133243695 cites W2022518367 @default.
- W133243695 cites W2025370055 @default.
- W133243695 cites W2027098220 @default.
- W133243695 cites W2027615576 @default.
- W133243695 cites W2028476252 @default.
- W133243695 cites W2028524759 @default.
- W133243695 cites W2030677912 @default.
- W133243695 cites W2030818396 @default.
- W133243695 cites W2031504285 @default.
- W133243695 cites W2033987226 @default.
- W133243695 cites W2034595626 @default.
- W133243695 cites W2034699234 @default.
- W133243695 cites W2038220785 @default.
- W133243695 cites W2039233803 @default.
- W133243695 cites W2040115542 @default.
- W133243695 cites W2040199078 @default.
- W133243695 cites W2040385253 @default.
- W133243695 cites W2042635405 @default.
- W133243695 cites W2047710431 @default.
- W133243695 cites W2048788553 @default.
- W133243695 cites W2050775594 @default.
- W133243695 cites W2052626837 @default.
- W133243695 cites W2052786158 @default.
- W133243695 cites W2058667428 @default.
- W133243695 cites W2061198459 @default.
- W133243695 cites W2066556226 @default.
- W133243695 cites W2067448997 @default.
- W133243695 cites W2068022987 @default.
- W133243695 cites W2069377303 @default.
- W133243695 cites W2069697787 @default.
- W133243695 cites W2072397543 @default.
- W133243695 cites W2073234761 @default.
- W133243695 cites W2073676627 @default.
- W133243695 cites W2074812494 @default.
- W133243695 cites W2076913561 @default.
- W133243695 cites W2077774191 @default.
- W133243695 cites W2079142742 @default.
- W133243695 cites W2080498914 @default.
- W133243695 cites W2083137416 @default.
- W133243695 cites W2083771852 @default.
- W133243695 cites W2087532087 @default.
- W133243695 cites W2088539970 @default.
- W133243695 cites W2093338662 @default.
- W133243695 cites W2093424029 @default.
- W133243695 cites W2095031669 @default.