Matches in SemOpenAlex for { <https://semopenalex.org/work/W133248150> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W133248150 endingPage "150" @default.
- W133248150 startingPage "150" @default.
- W133248150 abstract "Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors involved in various metabolic diseases. In the liver, PPARα is involved in alcohol metabolism and may lead to the development of alcoholic fatty liver and other alcohol mediated liver injuries. PPARβ modulation by ethanol induces abnormal myelin production by oligodendrocytes. PPARα and PPARβ are PPAR isoforms expressed in the human breast cell lines. Epidemiological studies show a positive correlation between alcohol intake and breast cancer risk, however, the molecular mechanisms involved are unclear. We hypothesized that ethanol would affect the expression and transactivation of human PPAR isoforms in estrogen receptor (ER) positive and ER negative breast cancer cells. Using real time RT-PCR we looked at the transcription of PPAR isoforms in the presence of increasing concentrations of ethanol and saw isoform and time dependent specific effects. Gene reporter assays enabled us to ascertain the effects of ethanol on ligand-mediated activation of human PPARα and PPARβ at concentrations equivalent to both moderate and chronic alcohol consumption. Ethanol differentially blocked the ligand-mediated activation of both PPARα and PPARβ. Since PPARα and PPARβ are involved in the differentiation and proliferation of breast cancer cells, PPARs may be a possible mechanism involved in the effect of ethanol in breast cancer." @default.
- W133248150 created "2016-06-24" @default.
- W133248150 creator A5031903138 @default.
- W133248150 creator A5055149798 @default.
- W133248150 creator A5067037288 @default.
- W133248150 creator A5087186958 @default.
- W133248150 date "2006-01-01" @default.
- W133248150 modified "2023-09-26" @default.
- W133248150 title "The effects of ethanol on PPARS in MCF-7 human breast cancer cells" @default.
- W133248150 hasPublicationYear "2006" @default.
- W133248150 type Work @default.
- W133248150 sameAs 133248150 @default.
- W133248150 citedByCount "0" @default.
- W133248150 crossrefType "journal-article" @default.
- W133248150 hasAuthorship W133248150A5031903138 @default.
- W133248150 hasAuthorship W133248150A5055149798 @default.
- W133248150 hasAuthorship W133248150A5067037288 @default.
- W133248150 hasAuthorship W133248150A5087186958 @default.
- W133248150 hasConcept C104317684 @default.
- W133248150 hasConcept C109541995 @default.
- W133248150 hasConcept C121608353 @default.
- W133248150 hasConcept C126322002 @default.
- W133248150 hasConcept C1292079 @default.
- W133248150 hasConcept C134018914 @default.
- W133248150 hasConcept C150194340 @default.
- W133248150 hasConcept C170493617 @default.
- W133248150 hasConcept C185592680 @default.
- W133248150 hasConcept C187345961 @default.
- W133248150 hasConcept C2994423619 @default.
- W133248150 hasConcept C502942594 @default.
- W133248150 hasConcept C530470458 @default.
- W133248150 hasConcept C53345823 @default.
- W133248150 hasConcept C55493867 @default.
- W133248150 hasConcept C63932345 @default.
- W133248150 hasConcept C71924100 @default.
- W133248150 hasConcept C84606932 @default.
- W133248150 hasConcept C86339819 @default.
- W133248150 hasConcept C86803240 @default.
- W133248150 hasConceptScore W133248150C104317684 @default.
- W133248150 hasConceptScore W133248150C109541995 @default.
- W133248150 hasConceptScore W133248150C121608353 @default.
- W133248150 hasConceptScore W133248150C126322002 @default.
- W133248150 hasConceptScore W133248150C1292079 @default.
- W133248150 hasConceptScore W133248150C134018914 @default.
- W133248150 hasConceptScore W133248150C150194340 @default.
- W133248150 hasConceptScore W133248150C170493617 @default.
- W133248150 hasConceptScore W133248150C185592680 @default.
- W133248150 hasConceptScore W133248150C187345961 @default.
- W133248150 hasConceptScore W133248150C2994423619 @default.
- W133248150 hasConceptScore W133248150C502942594 @default.
- W133248150 hasConceptScore W133248150C530470458 @default.
- W133248150 hasConceptScore W133248150C53345823 @default.
- W133248150 hasConceptScore W133248150C55493867 @default.
- W133248150 hasConceptScore W133248150C63932345 @default.
- W133248150 hasConceptScore W133248150C71924100 @default.
- W133248150 hasConceptScore W133248150C84606932 @default.
- W133248150 hasConceptScore W133248150C86339819 @default.
- W133248150 hasConceptScore W133248150C86803240 @default.
- W133248150 hasLocation W1332481501 @default.
- W133248150 hasOpenAccess W133248150 @default.
- W133248150 hasPrimaryLocation W1332481501 @default.
- W133248150 hasRelatedWork W195504466 @default.
- W133248150 hasRelatedWork W2024183861 @default.
- W133248150 hasRelatedWork W2044964190 @default.
- W133248150 hasRelatedWork W2068231503 @default.
- W133248150 hasRelatedWork W2107042749 @default.
- W133248150 hasRelatedWork W2119316267 @default.
- W133248150 hasRelatedWork W2141314779 @default.
- W133248150 hasRelatedWork W2144153275 @default.
- W133248150 hasRelatedWork W2194373590 @default.
- W133248150 hasRelatedWork W2241969818 @default.
- W133248150 hasRelatedWork W2342414790 @default.
- W133248150 hasRelatedWork W2375458161 @default.
- W133248150 hasRelatedWork W2385961131 @default.
- W133248150 hasRelatedWork W2397629063 @default.
- W133248150 hasRelatedWork W272997873 @default.
- W133248150 hasRelatedWork W2781588122 @default.
- W133248150 hasRelatedWork W2978535945 @default.
- W133248150 hasRelatedWork W3043071752 @default.
- W133248150 hasRelatedWork W3048549881 @default.
- W133248150 hasRelatedWork W54446527 @default.
- W133248150 isParatext "false" @default.
- W133248150 isRetracted "false" @default.
- W133248150 magId "133248150" @default.
- W133248150 workType "article" @default.