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• W133357620 abstract "Gonadal steroids play an important role in the regulation of neuroendocrine mechanisms involved in the reproductive function. In particular, through a feedback mechanism, they act on the synthesis and release of hypothalamic gonadotropinreleasing hormone (GnRH) and/or pituitary gonadotropic hormones (luteinizing hormone [LH] and follicle stimulating hormone [FSH]. Endogenous opioid peptides (EOP) represent one of the key factors mediating the activity of sex steroids on the hypothalamus-pituitary-gonadal (HPG) axis. Several data, both in animals and humans, indicate that the EOPs play a role in the feedback effect exerted by sex steroids on GnRH secretion. In particular, these peptides control the secretion of LH by inhibiting the hypothalamic GnRH release. Moreover, since EOPs modulate the activity of other neuronal pathways (GABAergic, noradrenergic, dopaminergic, serotoninergic, and cholinergic pathways), they are involved also in sexual behavior, thermoregulation, memory, feeding, pain, and immune response. Therefore a variety of central functions appear to be influenced by gonadal steroids, opioids, and neurotransmitters." @default.
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• W133357620 date "1994-01-01" @default.
• W133357620 modified "2023-09-27" @default.
• W133357620 title "Estrogens Modulation of Neuroendocrine Functions in Postmenopause" @default.
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• W133357620 doi "https://doi.org/10.1007/978-94-011-1024-2_25" @default.
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