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- W133359392 abstract "Brain metastases are a major cause of morbidity and mortality in patients with non–small cell lung carcinomas. However, effective therapies have not yet been developed. Targeted therapies based on driver genetic alterations are becoming standard treatment for patients with non-small cell lung carcinomas. Thus, effective therapy for brain metastases should be established based on the elucidation of critical genetic events related to metastases. Epidermal growth factor receptor or HER2 deregulation has been observed in brain metastatic tissue but had not been observed in primary lung carcinoma. Because there are readily available therapeutic agents for these abnormalities, targeted therapies that are more specific to brain metastases would be beneficial." @default.
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- W133359392 date "2015-01-01" @default.
- W133359392 modified "2023-09-23" @default.
- W133359392 title "Brain Metastasis from Non-Small Cell Lung Cancer: Use of Epidermal Growth Factor Receptor and HER2 Status for Targeted Therapy" @default.
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- W133359392 doi "https://doi.org/10.1016/b978-0-12-801419-6.00005-7" @default.
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