FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W133383503> ?p ?o ?g. }

• W133383503 endingPage "579" @default.
• W133383503 startingPage "571" @default.
• W133383503 abstract "The study investigated whether the number of participants enrolled per site in an acute heart failure trial is associated with participant characteristics and outcomes. Whether and how site enrollment volume affects clinical trials is not known. A total of 4,133 participants enrolled among 359 sites were grouped on the basis of total enrollment into 1 to 10, 11 to 30, and >30 participants per site and were compared for outcomes (cardiovascular mortality or heart failure hospitalization). Per-site enrollment ranged from 0 to 75 (median 6; 77 sites had no enrollment). Regional differences in enrollment were noted between North and South America, and Western and Eastern Europe (p < 0.001). Participants from sites with fewer enrollments were more likely to be older and male, have lower ejection fraction and blood pressure as well as worse comorbidity and laboratory profile, and were less likely to be on angiotensin-converting enzyme inhibitors or aldosterone antagonists. During a median follow-up of 9.9 months, 1,700 (41%) participants had an outcome event. Compared to event rate at sites with >30 participants (32%), those with 1 to 10 (51%, hazard ratio [HR]: 1.77, 95% confidence interval [CI]: 1.56 to 2.02) and 11 to 30 (42%, HR: 1.44, 95% CI: 1.28 to 1.62) participants per site groups had worse outcomes. This relationship was comparable across regions (p = 0.43). After adjustment for risk factors, participants enrolled at sites with fewer enrollees were at higher risk for adverse outcomes (HR: 1.26, 95% CI: 1.08 to 1.46 for 1 to 10; HR: 1.22, 95% CI: 1.07 to 1.38 for 11 to 30 vs. >30 participant sites). Higher proportion of participants from site with >30 participants completed the protocol (45.5% for <10, 61.7% for 11 to 30, and 68.4% for sites enrolling >30 participants; p < 0.001). Baseline characteristics, protocol completion, and outcomes differed significantly among higher versus lower enrolling sites. These data imply that the number of participant enrolled per site may influence trials beyond logistics." @default.
• W133383503 created "2016-06-24" @default.
• W133383503 creator A5011293667 @default.
• W133383503 creator A5015947834 @default.
• W133383503 creator A5017059544 @default.
• W133383503 creator A5036821495 @default.
• W133383503 creator A5040563784 @default.
• W133383503 creator A5051961415 @default.
• W133383503 creator A5061881316 @default.
• W133383503 creator A5068642565 @default.
• W133383503 creator A5079420772 @default.
• W133383503 creator A5080455302 @default.
• W133383503 creator A5085843860 @default.
• W133383503 creator A5088186128 @default.
• W133383503 date "2013-02-01" @default.
• W133383503 modified "2023-10-18" @default.
• W133383503 title "Relationship Between Clinical Trial Site Enrollment With Participant Characteristics, Protocol Completion, and Outcomes" @default.
• W133383503 cites W1965141396 @default.
• W133383503 cites W1973380773 @default.
• W133383503 cites W1973962628 @default.
• W133383503 cites W1983984269 @default.
• W133383503 cites W1992297716 @default.
• W133383503 cites W2013447687 @default.
• W133383503 cites W2029189814 @default.
• W133383503 cites W2049574314 @default.
• W133383503 cites W2087093792 @default.
• W133383503 cites W2092795856 @default.
• W133383503 cites W2121175754 @default.
• W133383503 cites W2141703599 @default.
• W133383503 cites W2142164422 @default.
• W133383503 cites W2155543018 @default.
• W133383503 cites W2164846898 @default.
• W133383503 cites W2169560588 @default.
• W133383503 cites W2212004723 @default.
• W133383503 cites W2548055034 @default.
• W133383503 cites W4230205158 @default.
• W133383503 doi "https://doi.org/10.1016/j.jacc.2012.10.025" @default.
• W133383503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23246389" @default.
• W133383503 hasPublicationYear "2013" @default.
• W133383503 type Work @default.
• W133383503 sameAs 133383503 @default.
• W133383503 citedByCount "57" @default.
• W133383503 countsByYear W1333835032013 @default.
• W133383503 countsByYear W1333835032014 @default.
• W133383503 countsByYear W1333835032015 @default.
• W133383503 countsByYear W1333835032016 @default.
• W133383503 countsByYear W1333835032017 @default.
• W133383503 countsByYear W1333835032018 @default.
• W133383503 countsByYear W1333835032020 @default.
• W133383503 countsByYear W1333835032021 @default.
• W133383503 crossrefType "journal-article" @default.
• W133383503 hasAuthorship W133383503A5011293667 @default.
• W133383503 hasAuthorship W133383503A5015947834 @default.
• W133383503 hasAuthorship W133383503A5017059544 @default.
• W133383503 hasAuthorship W133383503A5036821495 @default.
• W133383503 hasAuthorship W133383503A5040563784 @default.
• W133383503 hasAuthorship W133383503A5051961415 @default.
• W133383503 hasAuthorship W133383503A5061881316 @default.
• W133383503 hasAuthorship W133383503A5068642565 @default.
• W133383503 hasAuthorship W133383503A5079420772 @default.
• W133383503 hasAuthorship W133383503A5080455302 @default.
• W133383503 hasAuthorship W133383503A5085843860 @default.
• W133383503 hasAuthorship W133383503A5088186128 @default.
• W133383503 hasBestOaLocation W1333835031 @default.
• W133383503 hasConcept C126322002 @default.
• W133383503 hasConcept C144024400 @default.
• W133383503 hasConcept C149923435 @default.
• W133383503 hasConcept C168563851 @default.
• W133383503 hasConcept C197934379 @default.
• W133383503 hasConcept C207103383 @default.
• W133383503 hasConcept C2778198053 @default.
• W133383503 hasConcept C2779159551 @default.
• W133383503 hasConcept C44249647 @default.
• W133383503 hasConcept C535046627 @default.
• W133383503 hasConcept C71924100 @default.
• W133383503 hasConcept C78085059 @default.
• W133383503 hasConceptScore W133383503C126322002 @default.
• W133383503 hasConceptScore W133383503C144024400 @default.
• W133383503 hasConceptScore W133383503C149923435 @default.
• W133383503 hasConceptScore W133383503C168563851 @default.
• W133383503 hasConceptScore W133383503C197934379 @default.
• W133383503 hasConceptScore W133383503C207103383 @default.
• W133383503 hasConceptScore W133383503C2778198053 @default.
• W133383503 hasConceptScore W133383503C2779159551 @default.
• W133383503 hasConceptScore W133383503C44249647 @default.
• W133383503 hasConceptScore W133383503C535046627 @default.
• W133383503 hasConceptScore W133383503C71924100 @default.
• W133383503 hasConceptScore W133383503C78085059 @default.
• W133383503 hasFunder F4320307105 @default.
• W133383503 hasFunder F4320307770 @default.
• W133383503 hasFunder F4320307778 @default.
• W133383503 hasFunder F4320307813 @default.
• W133383503 hasFunder F4320308573 @default.
• W133383503 hasFunder F4320315432 @default.
• W133383503 hasFunder F4320318729 @default.
• W133383503 hasFunder F4320327235 @default.
• W133383503 hasIssue "5" @default.
• W133383503 hasLocation W1333835031 @default.

• next