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- W133399304 abstract "This chapter discusses that cultured keratinocytes provide a suitable model to study epidermal lipid metabolism in relation to keratinocyte differentiation. In this respect, air-exposed cultures are most attractive, because their resemblance to intact epidermal tissue is strong. Moreover, keratinocytes isolated from pathological skin specimens are in many cases able to maintain the morphogenic capabilities of their tissue of origin, and this offers a possibility of comparison with keratinocytes derived from the normal skin. This enables creation of conditions mimicking normal and pathological states in vitro and the possibility to evaluate biological responses at the cellular level. In a study on the effects of pharmacological agents, such as retinoids, glucocorticoids, or various additives of cosmetic preparations, two approaches can be used: (1) various modulators of differentiation can be added to the culture medium before elevating the culture to the air–liquid interface, and their effects on the epidermal differentiation program studied thereafter; and (2) pharmacological agents can be applied topically after completion of differentiation. Their effects on epidermal differentiation, lipid metabolism, and stratum corneum composition and barrier function can be then studied, thus affording an acceptable alternative to experiments with laboratory animals." @default.
- W133399304 created "2016-06-24" @default.
- W133399304 creator A5048949420 @default.
- W133399304 date "1991-01-01" @default.
- W133399304 modified "2023-10-17" @default.
- W133399304 title "Lipid Metabolism in Cultured Keratinocytes" @default.
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