Matches in SemOpenAlex for { <https://semopenalex.org/work/W133416341> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W133416341 endingPage "1149" @default.
- W133416341 startingPage "1146" @default.
- W133416341 abstract "Objective To determine the role of the NF-kappaB/I-kappaB pathway during ischemia reperfusion (I/R) injury to rat liver. Methords A group of rats underwent partial hepatic ischemia and reperfusion. The left and median lobe of the liver was subjected to ischemia for 90 minutes followed by reperfusion for previously specified periods. NF-kappaB activity was analyzed by electrophoretic mobility shift assay (EMSA). The protein level of I-kappaB was assessed using Western blot analysis. A semiquantitative reverse transcriptase polymerase chain reaction was used to analyze TNF-α and ICAM-1 mRNA levels. Results During liver I/R injury,NF-kappaB activation was induced in a time-dependent fashion. NF-kappaB was activated within 1 hour and 2 hours after the initiation of reperfusion and decreased afer 4 hours. The I-kappaB protein level was decreased in the cytoplasm after 2 hours, and the messenger RNA expression of TNF-α and ICAM-1 were increased simultaneously. Conclusions The data suggest that I-kappaB protein was degraded during hepatic I/R injury, NF kappaB was realeased and bound to special sequence in the promoters of budget genes, which regulated the expression of TNF-α and ICAM-1 mRNA. This provides evidence that the NF-kappaB/I-kappaB pathway plays an important modulating role in the expression of proinflammatory genes relevant to the development of ischemia reperfusion injury." @default.
- W133416341 created "2016-06-24" @default.
- W133416341 creator A5034719833 @default.
- W133416341 creator A5070841843 @default.
- W133416341 creator A5073862355 @default.
- W133416341 creator A5077834506 @default.
- W133416341 creator A5086407053 @default.
- W133416341 date "2003-07-08" @default.
- W133416341 modified "2023-09-25" @default.
- W133416341 title "NF-kappaB/I-kappaB pathway during ischemia reperfusion injury of the rat liver" @default.
- W133416341 hasPublicationYear "2003" @default.
- W133416341 type Work @default.
- W133416341 sameAs 133416341 @default.
- W133416341 citedByCount "0" @default.
- W133416341 crossrefType "journal-article" @default.
- W133416341 hasAuthorship W133416341A5034719833 @default.
- W133416341 hasAuthorship W133416341A5070841843 @default.
- W133416341 hasAuthorship W133416341A5073862355 @default.
- W133416341 hasAuthorship W133416341A5077834506 @default.
- W133416341 hasAuthorship W133416341A5086407053 @default.
- W133416341 hasConcept C104317684 @default.
- W133416341 hasConcept C105580179 @default.
- W133416341 hasConcept C126322002 @default.
- W133416341 hasConcept C134018914 @default.
- W133416341 hasConcept C150194340 @default.
- W133416341 hasConcept C153911025 @default.
- W133416341 hasConcept C164027704 @default.
- W133416341 hasConcept C177707886 @default.
- W133416341 hasConcept C183978625 @default.
- W133416341 hasConcept C2776415932 @default.
- W133416341 hasConcept C2776914184 @default.
- W133416341 hasConcept C2780114680 @default.
- W133416341 hasConcept C541997718 @default.
- W133416341 hasConcept C55493867 @default.
- W133416341 hasConcept C71924100 @default.
- W133416341 hasConcept C85265743 @default.
- W133416341 hasConcept C86803240 @default.
- W133416341 hasConceptScore W133416341C104317684 @default.
- W133416341 hasConceptScore W133416341C105580179 @default.
- W133416341 hasConceptScore W133416341C126322002 @default.
- W133416341 hasConceptScore W133416341C134018914 @default.
- W133416341 hasConceptScore W133416341C150194340 @default.
- W133416341 hasConceptScore W133416341C153911025 @default.
- W133416341 hasConceptScore W133416341C164027704 @default.
- W133416341 hasConceptScore W133416341C177707886 @default.
- W133416341 hasConceptScore W133416341C183978625 @default.
- W133416341 hasConceptScore W133416341C2776415932 @default.
- W133416341 hasConceptScore W133416341C2776914184 @default.
- W133416341 hasConceptScore W133416341C2780114680 @default.
- W133416341 hasConceptScore W133416341C541997718 @default.
- W133416341 hasConceptScore W133416341C55493867 @default.
- W133416341 hasConceptScore W133416341C71924100 @default.
- W133416341 hasConceptScore W133416341C85265743 @default.
- W133416341 hasConceptScore W133416341C86803240 @default.
- W133416341 hasIssue "7" @default.
- W133416341 hasLocation W1334163411 @default.
- W133416341 hasOpenAccess W133416341 @default.
- W133416341 hasPrimaryLocation W1334163411 @default.
- W133416341 hasRelatedWork W1963708974 @default.
- W133416341 hasRelatedWork W1997485025 @default.
- W133416341 hasRelatedWork W2002922356 @default.
- W133416341 hasRelatedWork W2010655321 @default.
- W133416341 hasRelatedWork W2016459948 @default.
- W133416341 hasRelatedWork W2049025940 @default.
- W133416341 hasRelatedWork W2052643501 @default.
- W133416341 hasRelatedWork W2059731503 @default.
- W133416341 hasRelatedWork W2351520354 @default.
- W133416341 hasRelatedWork W2353696937 @default.
- W133416341 hasRelatedWork W2355936748 @default.
- W133416341 hasRelatedWork W2364115828 @default.
- W133416341 hasRelatedWork W2370660788 @default.
- W133416341 hasRelatedWork W2374323169 @default.
- W133416341 hasRelatedWork W2376607284 @default.
- W133416341 hasRelatedWork W2389639050 @default.
- W133416341 hasRelatedWork W2390801526 @default.
- W133416341 hasRelatedWork W2397999978 @default.
- W133416341 hasRelatedWork W2409516189 @default.
- W133416341 hasRelatedWork W3029777641 @default.
- W133416341 hasVolume "116" @default.
- W133416341 isParatext "false" @default.
- W133416341 isRetracted "false" @default.
- W133416341 magId "133416341" @default.
- W133416341 workType "article" @default.