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• W133517047 abstract "Frogs were exposed to total-body irradiation of 200 r (at 10 r/min) from a distance of 16 cm. The brains were then investigated 2 hrs, and 2, 5, 7, and 11 days after exposure. Four hours before decapitation, 0.5 ml of aq NaH/sub 2/ Pu/sup 32/O/sub 4/ of a dosage of 25 mu C per 100 g weight, was administered by intraperitonal injection. The amount of acid-soluble P and its metabolism, the phospholipids, and the protein P of the brain were then investigated. Two hours after exposure, the total P-content in the acid-soluble fraction increased by 12.8% as compared with the control animals. The inorganic P-content increased by 11%, the total protein P by 21%, and the content of phospholipids decreased by 23.7%. These changes were even more marked after 2 days, when the total acid- soluble P fraction increased by 27.1%, out of which the inorganic P increased by 31%, the total protein P by 27.8% and the phospholipid content decreased by 42%. Six days after exposure, the total acid-soluble P fractions had increased up to 46.2% and the inorganic P-content by 87%. At the same time, however, the phospholipid content decreased by 23% and the content of proteinmore » P by 18%. Seven days after exposure the total acid-soluble P fraction increased by 50% but the total quantity of inorganic phosphate increased by 11.1% compared with the control animals. The phospholipid content was still decreased by 33% and the total protein P by 30%. Eleven days after exposure, the total acid-soluble P fraction was still increased by 45% out of which the inorganic P exceeded the values found in the control animals by 36%, the content of the phospholipids was again increased by 37%, and the content of the total protein P decreased by 39%. Thus the acid-soluble P fraction remained increased throughout the experiment, but the changes in protein P and phospholipids moved in opposite directions. After an initial increase in the protein P level a decrease could be observed, while the phospholipids showed an increase. Two hours after exposure, the rate of metabolism, as estimated by the relative specific activity of the fractions, showed changes parallel to those in the P content. After 2 to 5 days, the decrease of the specific activity in all fractions indicated a slowing down of the phosphate metabolism which reverted to its normal level after 8 to 12 days. (OTS)« less" @default.
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• W133517047 date "1962-01-01" @default.
• W133517047 modified "2023-09-27" @default.
• W133517047 title "THE INFLUENCE OF RADIATION UPON THE PHOSPHOROUS CONTENT AND ITS METABOLISM IN THE BRAIN" @default.
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