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• W133588037 abstract "Research Article1 February 1993free access Biogenesis of von Willebrand factor-containing organelles in heterologous transfected CV-1 cells. J. Voorberg J. Voorberg Department of Molecular Biology and Blood Coagulation, Central Laboratory, The Netherlands Red Cross Blood Transfusion Service, Amsterdam. Search for more papers by this author R. Fontijn R. Fontijn Department of Molecular Biology and Blood Coagulation, Central Laboratory, The Netherlands Red Cross Blood Transfusion Service, Amsterdam. Search for more papers by this author J. Calafat J. Calafat Department of Molecular Biology and Blood Coagulation, Central Laboratory, The Netherlands Red Cross Blood Transfusion Service, Amsterdam. Search for more papers by this author H. Janssen H. Janssen Department of Molecular Biology and Blood Coagulation, Central Laboratory, The Netherlands Red Cross Blood Transfusion Service, Amsterdam. Search for more papers by this author J.A. van Mourik J.A. van Mourik Department of Molecular Biology and Blood Coagulation, Central Laboratory, The Netherlands Red Cross Blood Transfusion Service, Amsterdam. Search for more papers by this author H. Pannekoek H. Pannekoek Department of Molecular Biology and Blood Coagulation, Central Laboratory, The Netherlands Red Cross Blood Transfusion Service, Amsterdam. Search for more papers by this author J. Voorberg J. Voorberg Department of Molecular Biology and Blood Coagulation, Central Laboratory, The Netherlands Red Cross Blood Transfusion Service, Amsterdam. Search for more papers by this author R. Fontijn R. Fontijn Department of Molecular Biology and Blood Coagulation, Central Laboratory, The Netherlands Red Cross Blood Transfusion Service, Amsterdam. Search for more papers by this author J. Calafat J. Calafat Department of Molecular Biology and Blood Coagulation, Central Laboratory, The Netherlands Red Cross Blood Transfusion Service, Amsterdam. Search for more papers by this author H. Janssen H. Janssen Department of Molecular Biology and Blood Coagulation, Central Laboratory, The Netherlands Red Cross Blood Transfusion Service, Amsterdam. Search for more papers by this author J.A. van Mourik J.A. van Mourik Department of Molecular Biology and Blood Coagulation, Central Laboratory, The Netherlands Red Cross Blood Transfusion Service, Amsterdam. Search for more papers by this author H. Pannekoek H. Pannekoek Department of Molecular Biology and Blood Coagulation, Central Laboratory, The Netherlands Red Cross Blood Transfusion Service, Amsterdam. Search for more papers by this author Author Information J. Voorberg1, R. Fontijn1, J. Calafat1, H. Janssen1, J.A. Mourik1 and H. Pannekoek1 1Department of Molecular Biology and Blood Coagulation, Central Laboratory, The Netherlands Red Cross Blood Transfusion Service, Amsterdam. The EMBO Journal (1993)12:749-758https://doi.org/10.1002/j.1460-2075.1993.tb05709.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Von Willebrand factor (vWF) is a multimeric protein involved in the adhesion of platelets to an injured vessel wall. vWF is synthesized by the endothelial cell and the megakaryocyte as a precursor protein (pro-vWF) that consists of four repeated domains, denoted D1-D2-D′-D3-A1-A2-A3-D4-B1-B2-B3-C1-C2. Previously, we have defined the domains on the pro-vWF molecule involved in dimerization as well as the domains involved in multimer assembly of vWF dimers. In the endothelial cell, part of the vWF multimers is stored in specialized organelles, the Weibel-Palade bodies. By using immunoelectron microscopy, we demonstrate that upon expression of full-length vWF cDNA, vWF-containing organelles are encountered in monkey kidney CV-1 cells that are morphologically similar to the endothelial-specific Weibel-Palade bodies. Expression in CV-1 cells of a series of vWF cDNA deletion mutants, lacking one or more domains, revealed that only those vWF mutant proteins that are able to assemble into multimers are encountered in dense-cored vesicles. Our data show that this process is independent of a particular domain on vWF and indicate that a ‘condensed’, multimeric vWF is required for targeting to the Weibel-Palade body. Previous ArticleNext Article Volume 12Issue 21 February 1993In this issue RelatedDetailsLoading ..." @default.
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• W133588037 date "1993-02-01" @default.
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• W133588037 title "Biogenesis of von Willebrand factor-containing organelles in heterologous transfected CV-1 cells." @default.
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