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• W133600335 abstract "A vaccination coverage survey was carried out in the Colombian Amazon, a former highendemic area for hepatitis B, involving 3573 children less than II years old. It was carriedout in Leticia, Puerto Narifio, and Araracuara, both urban and rural areas. Children wereselected using a one stage cluster sampling, randomly selecting clusters in urban and ruralareas where all children under 11 were surveyed. At the same time blood samples were takenfrom all children with known vaccination status (n=1603), and from their mother, when shewas available (n=8l2). These samples were processed for hepatitis B surface antigen(HBsAg), antibodies to hepatitis B core antigen (Anti-HBc) and antibodies to HBsAg (Anti-HBs). A sample of children without vaccination data available was also bled to comparetheir results with those of children with vaccination data.Full vaccination coverage was found to range between 39% and 69% among different areaswhile hepatitis B vaccination ranged between 73% and 95%. Factors which improve thelikelihood of being fully vaccinated in this study were: Age above one year, living in Leticia,being. affiliated to the social security, mother's years of schooling. Health worker'sknowledge on vaccine contraindications and perceptions of logistical barriers againstvaccination or importance of hepatitis B as a public health problem were also related to fullvaccine coverage.Prevalence of hepatitis B infection reached 5% among those who were bled (8211603) whileHBsAg positive status was 1.6% (26/1603). Since the introduction of the vaccine prevalenceof hepatitis B infection has fallen from 40%, an 85% reduction, while carrier prevalence hasfallen from 5%, a 68% reduction. Age above 7 years, living in a rural area, birth deliverysupervised by other than a MD or nurse, and being born from an Anti-HBc+ mother were themost important general factors related to being infected with HBV. Having an incompleteschedule for hepatitis B vaccine was associated with an increase in the risk of being Anti-HBc or HBsAg+. However, some characteristics of the vaccination process were related tobeing HBsAg+/Anti-HBc+. Delays in receiving the first dose of hepatitis B after birth anddelays to receiving the second dose after the first dose were associated with an increased riskof being HBsAg+/Anti-HBc+. None of these characteristics were related to being Anti-Hlic+alone.In conclusion, the introduction of a recombinant Cuban manufactured hepatitis B vaccine hasproduced a marked decline in the high infection prevalence of children in the ColombianAmazon area. A higher coverage has been achieved from the beginning of the programthough intervals from birth to first dose and between doses are too long leading to newinfections that could have been avoided.There is still room to make improvements in the control program, including theimplementation of a surveillance system of the HBV serological status for pregnant women,in order to ensure better vaccination schemes for those born to infected or HBsAg+ mothers." @default.
• W133600335 created "2016-06-24" @default.
• W133600335 creator A5031932749 @default.
• W133600335 date "2003-01-01" @default.
• W133600335 modified "2023-09-23" @default.
• W133600335 title "Hepatitis B vaccination in the Columbian Amazon : effectiveness and factors influencing vaccine coverage" @default.
• W133600335 doi "https://doi.org/10.17037/pubs.01544171" @default.
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