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- W133672178 abstract "The speed at which imaging technology continues to develop is touching all facets of biological study, and the field of epilepsy research is no exception. Our laboratories have taken advantage of the pivotal position that Ca2+ occupies in neuronal function, transducing electrical signals into molecular ones. Action potentials in neurons cause a transient rise in intracellular Ca2+, and so by loading the tissue with one of the many new fluorescent Ca2+ dyes, these Ca2+ transients can be followed in hundreds of cells simultaneously, with single cell resolution, at sampling rates of up to 60 Hz. Active cells literally light up, allowing those that display interesting activity patterns to be targeted for patch clamp characterization. Furthermore, these dyes have led to a resurgence of interest in glial cells by demonstrating hitherto unsuspected levels of activity in these cells, and indeed indicating a pivotal role for glial Ca2+ transients in ictogenesis. The high spatial and temporal resolution that Ca2+ imaging provides has allowed us to examine patterns of both physiological and pathological network activity. In particular, we have been able to visualize how feedforward inhibition opposes epileptiform spread, causing ictal events to progress only in a slow, stepwise fashion across the cortical network." @default.
- W133672178 created "2016-06-24" @default.
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- W133672178 date "2009-01-01" @default.
- W133672178 modified "2023-09-25" @default.
- W133672178 title "IMAGING | Optical Monitoring of Circuitry Activity In vitro" @default.
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- W133672178 doi "https://doi.org/10.1016/b978-012373961-2.00353-2" @default.
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