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• W133792508 abstract "The safety of the antioxidant α-lipoic acid (racemic form) (ALA), also called thioctic acid (CAS RN 1077-28-7) was assessed in acute and subchronic toxicity studies as well as in in vitro and in vivo mutagenicity/genotoxicity studies. ALA was not acutely toxic to rats (LD50 > 2000 mg/kg bw, OECD method 425). Administration of 31.6 or 61.9 mg ALA/kg bw/day for 4 weeks to male/female Wistar rats did not show any adverse effects. Specifically, there was no significant difference between control and treated animals at 31.6 or 61.9 mg ALA/kg bw with regard to body weight gain, feed consumption, animal behaviour, or haematological and clinical chemistry parameters. Only the high-dose of 121 mg ALA/kg bw was associated with slight alterations in liver enzymes as well as histopathological effects on the liver and mammary gland. ALA did not possess any mutagenic activity in the Ames assays conducted with various bacterial strains of Salmonella typhimurium. Moreover, there was no evidence of genotoxic activity in a mouse micronucleus assay. The results of these studies support the safety of ALA. The no-observed-adverse-effect level (NOAEL) is considered to be 61.9 mg/kg bw/day." @default.
• W133792508 created "2016-06-24" @default.
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• W133792508 date "2006-10-01" @default.
• W133792508 modified "2023-09-27" @default.
• W133792508 title "Safety evaluation of α-lipoic acid (ALA)" @default.
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• W133792508 doi "https://doi.org/10.1016/j.yrtph.2006.06.004" @default.
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