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- W133835312 endingPage "402" @default.
- W133835312 startingPage "381" @default.
- W133835312 abstract "From a developmental point of view, tumors can be seen as aberrant versions of their tissue of origin. For example, tumors often partially retain differentiation markers of their tissue of origin and there is evidence that they contain cancer stem cells (CSCs) that drive tumorigenesis. This chapter summarizes current evidence that breast CSCs may partly explain endocrine resistance in breast cancer. In normal breast, the stem cells are known to possess a basal phenotype and to be mainly estrogen receptor-α-negative (ER−). If the hierarchy in breast cancer reflects this, the breast CSC may be endocrine resistant because it expresses very little ER and can only respond to treatment by virtue of paracrine influences of neighboring, differentiated ER+ tumor cells. As we learn more about CSCs, differentiation, and the expression and function of the ER in these cells in diverse breast tumor subtypes, it is hoped that our understanding will lead to new modalities to overcome the problem of endocrine resistance in the clinic." @default.
- W133835312 created "2016-06-24" @default.
- W133835312 creator A5026261167 @default.
- W133835312 creator A5028638789 @default.
- W133835312 creator A5073495103 @default.
- W133835312 creator A5091730831 @default.
- W133835312 date "2011-01-01" @default.
- W133835312 modified "2023-09-27" @default.
- W133835312 title "Resistance to Endocrine Therapy in Breast Cancer: Are Breast Cancer Stem Cells Implicated?" @default.
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