Matches in SemOpenAlex for { <https://semopenalex.org/work/W134091864> ?p ?o ?g. }
- W134091864 endingPage "419" @default.
- W134091864 startingPage "395" @default.
- W134091864 abstract "The endoplasmic reticulum (ER) is recognized primarily as the site of synthesis and folding of secreted and membrane-bound proteins. The ER provides stringent quality control systems to ensure that only correctly folded, functional proteins are released from the ER and that misfolded proteins are degraded. The efficient functioning of the ER is essential for most cellular activities and for survival. Stimuli that interfere with ER function can disrupt ER homeostasis, impose stress to the ER, and subsequently cause accumulation of unfolded or misfolded proteins in the ER lumen. ER transmembrane proteins detect the onset of ER stress and initiate highly specific signaling pathways collectively called the unfolded protein response (UPR) to restore normal ER functions. However, if ER homeostasis cannot be reestablished in response to intense or prolonged ER stress, the UPR induces ER stress-associated apoptosis to protect the organism by removing the stressed cells that produce misfolded or malfunctioning proteins. This chapter summarizes current understanding of ER stress-induced apoptosis and reliable methods to examine ER stress and apoptosis in mammalian cells. Since the liver is the major organ dealing with metabolic or pathological stress and is responsible for the detoxification of chemical compounds, the experimental protocols described here focus on identification and characterization of ER stress-induced apoptosis in mouse liver." @default.
- W134091864 created "2016-06-24" @default.
- W134091864 creator A5011891226 @default.
- W134091864 creator A5015378855 @default.
- W134091864 date "2008-01-01" @default.
- W134091864 modified "2023-10-17" @default.
- W134091864 title "Chapter Twenty Identification and Characterization of Endoplasmic Reticulum Stress‐Induced Apoptosis In Vivo" @default.
- W134091864 cites W1519843125 @default.
- W134091864 cites W1905806846 @default.
- W134091864 cites W1964272444 @default.
- W134091864 cites W1965727325 @default.
- W134091864 cites W1965843055 @default.
- W134091864 cites W1967883750 @default.
- W134091864 cites W1970090817 @default.
- W134091864 cites W1972482541 @default.
- W134091864 cites W1975290731 @default.
- W134091864 cites W1985339713 @default.
- W134091864 cites W1986737010 @default.
- W134091864 cites W1991999080 @default.
- W134091864 cites W1995301389 @default.
- W134091864 cites W1995483143 @default.
- W134091864 cites W1996952569 @default.
- W134091864 cites W2010454897 @default.
- W134091864 cites W2012166934 @default.
- W134091864 cites W2019192392 @default.
- W134091864 cites W2025518316 @default.
- W134091864 cites W2029642537 @default.
- W134091864 cites W2031735388 @default.
- W134091864 cites W2034213169 @default.
- W134091864 cites W2034505413 @default.
- W134091864 cites W2034810866 @default.
- W134091864 cites W2039379491 @default.
- W134091864 cites W2042173490 @default.
- W134091864 cites W2054820743 @default.
- W134091864 cites W2064122617 @default.
- W134091864 cites W2069924169 @default.
- W134091864 cites W2076485183 @default.
- W134091864 cites W2077308121 @default.
- W134091864 cites W2080901528 @default.
- W134091864 cites W2089198803 @default.
- W134091864 cites W2093158584 @default.
- W134091864 cites W2095448583 @default.
- W134091864 cites W2100347985 @default.
- W134091864 cites W2100948166 @default.
- W134091864 cites W2103483160 @default.
- W134091864 cites W2107601804 @default.
- W134091864 cites W2110682723 @default.
- W134091864 cites W2112286580 @default.
- W134091864 cites W2112300479 @default.
- W134091864 cites W2115205812 @default.
- W134091864 cites W2119902047 @default.
- W134091864 cites W2127639686 @default.
- W134091864 cites W2127906377 @default.
- W134091864 cites W2130092335 @default.
- W134091864 cites W2131632095 @default.
- W134091864 cites W2133425838 @default.
- W134091864 cites W2133705052 @default.
- W134091864 cites W2136729555 @default.
- W134091864 cites W2139568257 @default.
- W134091864 cites W2140187466 @default.
- W134091864 cites W2140429847 @default.
- W134091864 cites W2140974913 @default.
- W134091864 cites W2141686439 @default.
- W134091864 cites W2144135883 @default.
- W134091864 cites W2146870223 @default.
- W134091864 cites W2155884826 @default.
- W134091864 cites W2163285372 @default.
- W134091864 cites W2168415166 @default.
- W134091864 cites W4240150566 @default.
- W134091864 cites W4245041543 @default.
- W134091864 cites W4250374989 @default.
- W134091864 doi "https://doi.org/10.1016/s0076-6879(08)01420-1" @default.
- W134091864 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2865177" @default.
- W134091864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18662581" @default.
- W134091864 hasPublicationYear "2008" @default.
- W134091864 type Work @default.
- W134091864 sameAs 134091864 @default.
- W134091864 citedByCount "81" @default.
- W134091864 countsByYear W1340918642012 @default.
- W134091864 countsByYear W1340918642013 @default.
- W134091864 countsByYear W1340918642014 @default.
- W134091864 countsByYear W1340918642015 @default.
- W134091864 countsByYear W1340918642016 @default.
- W134091864 countsByYear W1340918642017 @default.
- W134091864 countsByYear W1340918642018 @default.
- W134091864 countsByYear W1340918642019 @default.
- W134091864 countsByYear W1340918642020 @default.
- W134091864 countsByYear W1340918642021 @default.
- W134091864 countsByYear W1340918642022 @default.
- W134091864 countsByYear W1340918642023 @default.
- W134091864 crossrefType "book-chapter" @default.
- W134091864 hasAuthorship W134091864A5011891226 @default.
- W134091864 hasAuthorship W134091864A5015378855 @default.
- W134091864 hasBestOaLocation W1340918642 @default.
- W134091864 hasConcept C139447449 @default.
- W134091864 hasConcept C158617107 @default.
- W134091864 hasConcept C170493617 @default.
- W134091864 hasConcept C185592680 @default.