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- W1344697 abstract "This chapter discusses a possible mechanism of protein synthesis inhibition by eukaryotic initiation factor-2 (eIF-2) kinases, heme-regulated protein synthesis inhibitor, and double-stranded RNA-activated inhibitor; it discusses the roles of four eIF-2 ancillary protein factors in the complex regulation of protein synthesis initiation in animal cells. The loss of interaction of eIF-2α(P) with Co-eIF-2B and Co-eIF-2C has been suggested as the mechanism of protein synthesis inhibition by eIF-2 kinases. However, a direct evidence that the formation of eIF-2α(P) and consequent loss of interaction of eIF-2α(P) with Co-eIF-2B and Co-eIF-2C are the sole cause of protein synthesis inhibition in heme-deficient reticulocyte lysates is still lacking. The four eIF-2 ancillary factors, Co-eIF-2A, Co-eIF-2B, Co-eIF-2C, and reversal factor, have been characterized by their effects on eIF-2 activity in vitro. The requirement for Co-eIF-2A for protein synthesis in reticulocyte lysates is shown by using antibodies. It has not yet been possible to reconstitute from purified components an efficient protein-synthesizing system with which to examine the requirements for specific factors in overall peptide chain initiation." @default.
- W1344697 created "2016-06-24" @default.
- W1344697 creator A5027884511 @default.
- W1344697 date "1982-01-01" @default.
- W1344697 modified "2023-10-15" @default.
- W1344697 title "Roles of Eukaryotic Initiation Factor 2 Ancillary Factors in the Regulation of Eukaryotic Protein Synthesis Initiation" @default.
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- W1344697 doi "https://doi.org/10.1016/b978-0-12-152821-8.50005-0" @default.
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