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• W134485649 startingPage "145" @default.
• W134485649 abstract "The p53 protein was first identified through its ability to co-precipitate with the large T antigen of simian virus 40 (SV40) (DeLeo et al. 1979; Kress et al. 1979; Lane and Crawford 1979; Linzer and Levine 1979). The gene was subsequently cloned from several species (reviewed by Soussi et al. 1990), and was first suggested to function as an oncogene since overexpression of p53 was reported to participate in cell transformation (Eliyahu et at. 1984; Parada et al. 1984). However, in the late 1980s it became clear that the oncogenic activities of p53 were exhibited by mutant forms of the protein (Eliyahu et al. 1988; Finlay et al. 1988; Hinds et al. 1989). Genetic evidence suggested in fact that the wild-type (wt) form of the p53 gene could be defined as a tumor suppressor gene. Mutations in p53 were found to occur in high frequency in colon cancer (Baker et al. 1989), and this observation was later extended to most of the common types of human cancer (Hollstein et al. 1994)." @default.
• W134485649 created "2016-06-24" @default.
• W134485649 creator A5013649030 @default.
• W134485649 creator A5049042523 @default.
• W134485649 creator A5083437983 @default.
• W134485649 date "1999-01-01" @default.
• W134485649 modified "2023-10-18" @default.
• W134485649 title "The p53 Tumor Suppressor Gene: Structure, Function and Mechanism of Action" @default.
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