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- W134508743 abstract "Calcium channel blockers are now widely used for the treatment of hypertension and angina. However, recent evidence suggests that calcium channel blockers may also be beneficial in controlling processes leading to atherosclerosis. In these studies, we evaluated the effects of two dihydropyridine calcium channel blockers, Nifedipine and Nicardipine on cholesterol metabolism in aortic smooth muscle cells. Nicardipine increased LDL receptor activity that was paralleled by an increase in the steady state level of LDL receptor mRNA. These calcium channel blockers also increased lysosomal and cytoplasmic cholesteryl ester hydrolase activities, but did not alter ACAT activity. Since we have demonstrated that these processes are modulated by prostacyclin (PGI2) and cyclic AMP, we evaluated the effects of calcium channel blockers on PGI2 release and cyclic AMP levels. We found that these agents increased both PGI2 release and cyclic AMP production. Finally, several calcium channel blockers reduced cholesterol content in cholesterol-enriched smooth muscle cells derived from atherosclerotic rabbits, and reduced cholesterol content in aortic biopsies taken from patients undergoing coronary bypass surgery. Taken together, our data demonstrate that calcium channel blockers reduce cholesterol content in vascular tissue by stimulating LDL catabolism through a process that is mediated by PGL2 and cyclic AMP. Our results engender support for the use of calcium channel blockers as anti-atherosclerotic agents." @default.
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- W134508743 date "1993-01-01" @default.
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- W134508743 title "Biochemical Mechanisms Associated with the Lipolytic Effects of Calcium Channel Blockers" @default.
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- W134508743 doi "https://doi.org/10.1007/978-94-011-1703-6_31" @default.
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