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- W134611992 abstract "This chapter describes a study that was undertaken to determine whether or not biguanides modify the incidence of abnormalities in rabbits that are fed a high-cholesterol or high-fat diet. In the normal animals, after administration of metformin for two months, the level of cholesterol esters in the plasma was lowered slightly and the free fatty acids (FFA) were slightly increased. The composition and morphological aspects of the liver and the arteries were unaffected. The esterified cholesterol mean content of the arteries increased during the first three months. After four months, it was still elevated to 385. A histological examination of the vessels also revealed aggravation of the lesions after three months of normal diet and the presence of lipidofibrillar plaques after four months, which were never observed after two months of the cholesterol diet. Metformin did not prevent further development of plaques already formed, although the elimination of cholesterol was accelerated. The reversible lesions in the abdominal aorta were significantly improved." @default.
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- W134611992 date "1973-01-01" @default.
- W134611992 modified "2023-09-25" @default.
- W134611992 title "The Effects of Metformin on Lipid-Induced Atherosclerosis" @default.
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- W134611992 doi "https://doi.org/10.1016/b978-0-12-027362-1.50065-0" @default.
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