Matches in SemOpenAlex for { <https://semopenalex.org/work/W134718897> ?p ?o ?g. }
- W134718897 endingPage "8" @default.
- W134718897 startingPage "51" @default.
- W134718897 abstract "Matrix metalloproteinase-9 is involved in inflammation and tumor progression. We previously demonstrated that interferon type I (alpha/beta) and II (gamma) inhibit matrix metalloproteinase-9 (92kDa) gene expression on lymphocytes from patients with B chronic lymphocytic leukemia and human monocytes. Since all-trans retinoic acid (ATRA) can regulate some interferon -responsive genes, we studied here the effects of all-trans retinoic acid onto matrix metalloproteinase-9 levels in these cells. By using RT-PCR, ELISA and zymography experiments, we showed that all-trans retinoic acid down-regulated matrix metalloproteinase-9 synthesis (mRNA,protein) and secretion. The inhibitory action of all-trans retinoic acid toward matrix metalloproteinase-9 was however not associated with the STAT1/IRF-1 pathway involved in interferon-mediated matrix metalloproteinase-9 inhibition indicating that all-trans retinoic acid did not bypass IFN receptor signaling. Using flow cytometry, we detected on the surface of monocytes low expression of matrix metalloproteinase-9 and Fc-gammaRI, and high expression of HLA-DR, beta1 and beta2 integrins. Enhancement of Fc-gammaRI and HLA-DR on monocytes by interferon-gamma, but not by all-trans retinoic acid, was accompanied by up-regulation of surface matrix metalloproteinase-9. Furthermore, we showed that all-trans retinoic acid down-regulated matrix metalloproteinase-9 expression in lymphocytes of untreated patients with early stage B chronic lymphocytic leukemia. Together, our data suggest the potential relevance of all-trans retinoic acid as a pharmacological tool to attenuate matrix metalloproteinase-9 secretion in pathological situations." @default.
- W134718897 created "2016-06-24" @default.
- W134718897 creator A5011628055 @default.
- W134718897 creator A5070668456 @default.
- W134718897 creator A5080624303 @default.
- W134718897 date "2006-05-15" @default.
- W134718897 modified "2023-09-25" @default.
- W134718897 title "Comparative effects of interferon-gamma and all- trans retinoic acid on secreted and surface-associated matrix metalloproteinase-9 expression of human monocytes." @default.
- W134718897 cites W1484664712 @default.
- W134718897 cites W1505042995 @default.
- W134718897 cites W1513111138 @default.
- W134718897 cites W1525484196 @default.
- W134718897 cites W1569016295 @default.
- W134718897 cites W1573411722 @default.
- W134718897 cites W181337481 @default.
- W134718897 cites W1881589758 @default.
- W134718897 cites W1922883684 @default.
- W134718897 cites W1966150990 @default.
- W134718897 cites W1969133782 @default.
- W134718897 cites W1969191130 @default.
- W134718897 cites W1972115931 @default.
- W134718897 cites W1972385590 @default.
- W134718897 cites W1972513376 @default.
- W134718897 cites W1973308380 @default.
- W134718897 cites W1987825791 @default.
- W134718897 cites W2004323635 @default.
- W134718897 cites W2008025255 @default.
- W134718897 cites W2019048131 @default.
- W134718897 cites W2020546557 @default.
- W134718897 cites W2021502161 @default.
- W134718897 cites W2025600767 @default.
- W134718897 cites W2026287156 @default.
- W134718897 cites W2031604577 @default.
- W134718897 cites W2035505274 @default.
- W134718897 cites W2038051305 @default.
- W134718897 cites W2039000210 @default.
- W134718897 cites W2051523398 @default.
- W134718897 cites W2065285477 @default.
- W134718897 cites W2078480515 @default.
- W134718897 cites W2086403021 @default.
- W134718897 cites W2089260591 @default.
- W134718897 cites W2098782252 @default.
- W134718897 cites W2103152132 @default.
- W134718897 cites W2117583924 @default.
- W134718897 cites W2120215651 @default.
- W134718897 cites W2127378869 @default.
- W134718897 cites W2147818333 @default.
- W134718897 cites W2148397698 @default.
- W134718897 cites W2151385573 @default.
- W134718897 cites W2153619885 @default.
- W134718897 cites W2157801045 @default.
- W134718897 cites W2160669858 @default.
- W134718897 cites W2166144109 @default.
- W134718897 cites W2167017590 @default.
- W134718897 cites W2168507682 @default.
- W134718897 cites W2181597476 @default.
- W134718897 cites W2245941149 @default.
- W134718897 cites W2314507989 @default.
- W134718897 cites W2315168692 @default.
- W134718897 cites W2403848809 @default.
- W134718897 cites W2410882463 @default.
- W134718897 cites W2411260605 @default.
- W134718897 cites W65867874 @default.
- W134718897 cites W2145760800 @default.
- W134718897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16914095" @default.
- W134718897 hasPublicationYear "2006" @default.
- W134718897 type Work @default.
- W134718897 sameAs 134718897 @default.
- W134718897 citedByCount "1" @default.
- W134718897 countsByYear W1347188972017 @default.
- W134718897 crossrefType "journal-article" @default.
- W134718897 hasAuthorship W134718897A5011628055 @default.
- W134718897 hasAuthorship W134718897A5070668456 @default.
- W134718897 hasAuthorship W134718897A5080624303 @default.
- W134718897 hasConcept C104317684 @default.
- W134718897 hasConcept C109523444 @default.
- W134718897 hasConcept C119775778 @default.
- W134718897 hasConcept C120197328 @default.
- W134718897 hasConcept C153911025 @default.
- W134718897 hasConcept C185592680 @default.
- W134718897 hasConcept C19431177 @default.
- W134718897 hasConcept C2775958869 @default.
- W134718897 hasConcept C2779963572 @default.
- W134718897 hasConcept C2781121885 @default.
- W134718897 hasConcept C502942594 @default.
- W134718897 hasConcept C55493867 @default.
- W134718897 hasConcept C86803240 @default.
- W134718897 hasConceptScore W134718897C104317684 @default.
- W134718897 hasConceptScore W134718897C109523444 @default.
- W134718897 hasConceptScore W134718897C119775778 @default.
- W134718897 hasConceptScore W134718897C120197328 @default.
- W134718897 hasConceptScore W134718897C153911025 @default.
- W134718897 hasConceptScore W134718897C185592680 @default.
- W134718897 hasConceptScore W134718897C19431177 @default.
- W134718897 hasConceptScore W134718897C2775958869 @default.
- W134718897 hasConceptScore W134718897C2779963572 @default.
- W134718897 hasConceptScore W134718897C2781121885 @default.
- W134718897 hasConceptScore W134718897C502942594 @default.