FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W13483752> ?p ?o ?g. }

• W13483752 abstract "In multicellular organisms, determining when and where genes will be expressed is critical for their development and physiology. Transcription factors (TFs) are major specifiers of differential gene expression. By establishing physical contacts with the regulatory elements of their target genes, TFs often determine whether the target genes will be expressed or not. These physical and/or regulatory TF-DNA interactions can be modeled into gene regulatory networks (GRNs), which provide a systems-level view of differential gene expression. Thus far, much of the GRN delineation efforts focused on metazoan development, whereas the organization of GRNs that pertain to systems physiology remains mostly unexplored. My work has focused on delineating the first gene regulatory network of the nematode Caenorhabditis elegans metabolic genes, and investigating how this network relates to the energy homeostasis of the nematode. The resulting metabolic GRN consists of ~70 metabolic genes, 100 TFs and more than 500 protein–DNA interactions. It also includes novel protein-protein interactions involving the metabolic transcriptional cofactor MDT-15 and several TFs that occur in the metabolic GRN. On a global level, we found that the metabolic GRN is enriched for nuclear hormone receptors (NHRs). NHRs form a special class of TFs that can interact with diffusible biomolecules and are well-known regulators of lipid metabolism in other organisms, including humans. Interestingly, NHRs comprise the largest family of TFs in nematodes; the C. elegans genome encodes 284 NHRs, most of which are uncharacterized. In our study, we show that the C. elegans NHRs that we retrieved in the metabolic GRN organize into network modules, and that most of these NHRs function to maintain lipid homeostasis in the nematode. Network modularity has been proposed to facilitate rapid and robust changes in gene expression. Our results suggest that the C. elegans metabolic GRN may have evolved by combining NHR family expansion with the specific modular wiring of NHRs to enable the rapid adaptation of the animal to different environmental cues." @default.
• W13483752 created "2016-06-24" @default.
• W13483752 creator A5084049190 @default.
• W13483752 date "2010-01-01" @default.
• W13483752 modified "2023-10-03" @default.
• W13483752 title "C. Elegans Metabolic Gene Regulatory Networks: A Dissertation" @default.
• W13483752 cites W1563231805 @default.
• W13483752 cites W1631908837 @default.
• W13483752 cites W1861035294 @default.
• W13483752 cites W1944127002 @default.
• W13483752 cites W1964876127 @default.
• W13483752 cites W1965105878 @default.
• W13483752 cites W1965637603 @default.
• W13483752 cites W1971225285 @default.
• W13483752 cites W1971421925 @default.
• W13483752 cites W1975036436 @default.
• W13483752 cites W1975539651 @default.
• W13483752 cites W1983057459 @default.
• W13483752 cites W1983825024 @default.
• W13483752 cites W1985865142 @default.
• W13483752 cites W1987735513 @default.
• W13483752 cites W1989187403 @default.
• W13483752 cites W1991484745 @default.
• W13483752 cites W1992696908 @default.
• W13483752 cites W1995008569 @default.
• W13483752 cites W1995754186 @default.
• W13483752 cites W1999580573 @default.
• W13483752 cites W1999989614 @default.
• W13483752 cites W2002574233 @default.
• W13483752 cites W2004743215 @default.
• W13483752 cites W2004775480 @default.
• W13483752 cites W2006367501 @default.
• W13483752 cites W2006837755 @default.
• W13483752 cites W2008620264 @default.
• W13483752 cites W2012150397 @default.
• W13483752 cites W2012383052 @default.
• W13483752 cites W2014946489 @default.
• W13483752 cites W2015157204 @default.
• W13483752 cites W2018045523 @default.
• W13483752 cites W2019136439 @default.
• W13483752 cites W2019670773 @default.
• W13483752 cites W2024060441 @default.
• W13483752 cites W2028867856 @default.
• W13483752 cites W2031058471 @default.
• W13483752 cites W2032579724 @default.
• W13483752 cites W2033525251 @default.
• W13483752 cites W2035733956 @default.
• W13483752 cites W2038492783 @default.
• W13483752 cites W2039307052 @default.
• W13483752 cites W2039999119 @default.
• W13483752 cites W2043426556 @default.
• W13483752 cites W2046048837 @default.
• W13483752 cites W2046753623 @default.
• W13483752 cites W2047649079 @default.
• W13483752 cites W2049220511 @default.
• W13483752 cites W2049408087 @default.
• W13483752 cites W2056970473 @default.
• W13483752 cites W2061425021 @default.
• W13483752 cites W2064631117 @default.
• W13483752 cites W2065958815 @default.
• W13483752 cites W2072897152 @default.
• W13483752 cites W2076524169 @default.
• W13483752 cites W2077159940 @default.
• W13483752 cites W2079080809 @default.
• W13483752 cites W2079818352 @default.
• W13483752 cites W2080498142 @default.
• W13483752 cites W2081146141 @default.
• W13483752 cites W2083501474 @default.
• W13483752 cites W2083752219 @default.
• W13483752 cites W2084856509 @default.
• W13483752 cites W2087072206 @default.
• W13483752 cites W2088026826 @default.
• W13483752 cites W2097469177 @default.
• W13483752 cites W2097794559 @default.
• W13483752 cites W2098056422 @default.
• W13483752 cites W2098412979 @default.
• W13483752 cites W2099057503 @default.
• W13483752 cites W2099971177 @default.
• W13483752 cites W2100221195 @default.
• W13483752 cites W2101211308 @default.
• W13483752 cites W2101400941 @default.
• W13483752 cites W2102840368 @default.
• W13483752 cites W2102893759 @default.
• W13483752 cites W2104011136 @default.
• W13483752 cites W2107536811 @default.
• W13483752 cites W2108726522 @default.
• W13483752 cites W2109110326 @default.
• W13483752 cites W2110247397 @default.
• W13483752 cites W2112019511 @default.
• W13483752 cites W2112743993 @default.
• W13483752 cites W2112928083 @default.
• W13483752 cites W2113019448 @default.
• W13483752 cites W2114459962 @default.
• W13483752 cites W2115573707 @default.
• W13483752 cites W2115810854 @default.
• W13483752 cites W2117132491 @default.
• W13483752 cites W2118000816 @default.
• W13483752 cites W2122163057 @default.
• W13483752 cites W2126414770 @default.
• W13483752 cites W2126606094 @default.

• next