Matches in SemOpenAlex for { <https://semopenalex.org/work/W134975557> ?p ?o ?g. }
- W134975557 endingPage "289" @default.
- W134975557 startingPage "279" @default.
- W134975557 abstract "Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy with an aggressive clinical course. Most patients with BPDCN have skin lesions and simultaneous involvement of the peripheral blood, bone marrow, and lymph nodes.A search of PubMed and Medline was conducted for English-written articles relating to BPDCN, CD4(+)CD56(+) hematodermic neoplasm, and blastic natural killer cell lymphoma. Data regarding diagnosis, prognosis, and treatment were analyzed.BPDCN is derived from precursor plasmacytoid dendritic cells. The diagnosis of BPDCN is based on the characteristic cytology and immunophenotype of malignant cells coexpressing CD4, CD56, CD123, blood dendritic cell antigens 2 and 4, and CD2AP markers. Multiple chromosomal abnormalities and gene mutations previously reported in patients with myeloid and selected lymphoid neoplasms were identified in approximately 60% of patients with BPDCN. Prospectively controlled studies to guide treatment decisions are lacking. The overall response rate with aggressive acute lymphoblastic leukemia-type induction regimens was as high as 90%, but the durability of response was short. Median survival rates ranged between 12 and 16 months. Patients with relapsed disease may respond to L-asparaginase-containing regimens. Allogeneic hematopoietic stem cell transplantation, particularly when performed during the first remission, may produce durable remissions in selected adults.BPDCN is a rare aggressive disease that typically affects elderly patients. The most commonly affected nonhematopoietic organ is the skin. Although BPDCN is initially sensitive to conventional chemotherapy regimens, this response is relatively short and long-term prognosis is poor. In the near future, novel targeted therapies may improve outcomes for patients with BPDCN." @default.
- W134975557 created "2016-06-24" @default.
- W134975557 creator A5007743410 @default.
- W134975557 creator A5037214066 @default.
- W134975557 creator A5063876159 @default.
- W134975557 creator A5088253834 @default.
- W134975557 date "2014-10-01" @default.
- W134975557 modified "2023-10-14" @default.
- W134975557 title "Blastic Plasmacytoid Dendritic Cell Neoplasm: Update on Molecular Biology, Diagnosis, and Therapy" @default.
- W134975557 cites W1493509974 @default.
- W134975557 cites W1837925017 @default.
- W134975557 cites W1963511273 @default.
- W134975557 cites W1968216333 @default.
- W134975557 cites W1970573066 @default.
- W134975557 cites W1970748013 @default.
- W134975557 cites W1971376068 @default.
- W134975557 cites W1972741048 @default.
- W134975557 cites W1975995958 @default.
- W134975557 cites W1978030902 @default.
- W134975557 cites W1984199157 @default.
- W134975557 cites W1985207223 @default.
- W134975557 cites W1989922145 @default.
- W134975557 cites W1993937549 @default.
- W134975557 cites W1994187282 @default.
- W134975557 cites W1996445626 @default.
- W134975557 cites W1998650989 @default.
- W134975557 cites W2001675076 @default.
- W134975557 cites W2002564743 @default.
- W134975557 cites W2011741581 @default.
- W134975557 cites W2016498285 @default.
- W134975557 cites W2018997248 @default.
- W134975557 cites W2020115492 @default.
- W134975557 cites W2026485577 @default.
- W134975557 cites W2028278418 @default.
- W134975557 cites W2028911106 @default.
- W134975557 cites W2031041045 @default.
- W134975557 cites W2036671707 @default.
- W134975557 cites W2045683870 @default.
- W134975557 cites W2045821716 @default.
- W134975557 cites W2047255745 @default.
- W134975557 cites W2050328060 @default.
- W134975557 cites W2056486998 @default.
- W134975557 cites W2061929136 @default.
- W134975557 cites W2073408113 @default.
- W134975557 cites W2078744027 @default.
- W134975557 cites W2085242390 @default.
- W134975557 cites W2087202688 @default.
- W134975557 cites W2089243465 @default.
- W134975557 cites W2095384811 @default.
- W134975557 cites W2097881820 @default.
- W134975557 cites W2098085913 @default.
- W134975557 cites W2110201385 @default.
- W134975557 cites W2113116401 @default.
- W134975557 cites W2115497973 @default.
- W134975557 cites W2117053011 @default.
- W134975557 cites W2124134057 @default.
- W134975557 cites W2126854258 @default.
- W134975557 cites W2126972630 @default.
- W134975557 cites W2128964874 @default.
- W134975557 cites W2140463317 @default.
- W134975557 cites W2145650308 @default.
- W134975557 cites W2147937183 @default.
- W134975557 cites W2149405895 @default.
- W134975557 cites W2156308068 @default.
- W134975557 cites W2314987545 @default.
- W134975557 cites W2328336243 @default.
- W134975557 cites W2474556890 @default.
- W134975557 cites W2601837163 @default.
- W134975557 cites W4254071739 @default.
- W134975557 cites W4297067629 @default.
- W134975557 doi "https://doi.org/10.1177/107327481402100404" @default.
- W134975557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25310209" @default.
- W134975557 hasPublicationYear "2014" @default.
- W134975557 type Work @default.
- W134975557 sameAs 134975557 @default.
- W134975557 citedByCount "64" @default.
- W134975557 countsByYear W1349755572014 @default.
- W134975557 countsByYear W1349755572015 @default.
- W134975557 countsByYear W1349755572016 @default.
- W134975557 countsByYear W1349755572017 @default.
- W134975557 countsByYear W1349755572018 @default.
- W134975557 countsByYear W1349755572019 @default.
- W134975557 countsByYear W1349755572020 @default.
- W134975557 countsByYear W1349755572021 @default.
- W134975557 countsByYear W1349755572022 @default.
- W134975557 countsByYear W1349755572023 @default.
- W134975557 crossrefType "journal-article" @default.
- W134975557 hasAuthorship W134975557A5007743410 @default.
- W134975557 hasAuthorship W134975557A5037214066 @default.
- W134975557 hasAuthorship W134975557A5063876159 @default.
- W134975557 hasAuthorship W134975557A5088253834 @default.
- W134975557 hasBestOaLocation W1349755571 @default.
- W134975557 hasConcept C126322002 @default.
- W134975557 hasConcept C143998085 @default.
- W134975557 hasConcept C147483822 @default.
- W134975557 hasConcept C196166836 @default.
- W134975557 hasConcept C203014093 @default.
- W134975557 hasConcept C2776051438 @default.