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- W135045138 abstract "GABA and glycine are classically called inhibitory amino acids, despite the fact that their action can rapidly switch from inhibition to excitation and vice versa. The postsynaptic action depends on the intracellular concentration of chloride ions ([Cl(-)](i)), which is regulated by proteins in the plasma membrane: the K(+)-Cl(-) cotransporter KCC2 and the Na(+)-K(+)-Cl(-) cotransporter NKCC1, which extrude and intrude Cl(-) ions, respectively. A high [Cl(-)](i) leads to a depolarizing (excitatory) action of GABA and glycine, as observed in mature dorsal root ganglion neurons and in motoneurons both early during development and in several pathological conditions, such as following spinal cord injury. Here, we review some recent data regarding chloride homeostasis in the spinal cord and its contribution to network operation involved in locomotion." @default.
- W135045138 created "2016-06-24" @default.
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- W135045138 date "2011-01-01" @default.
- W135045138 modified "2023-10-15" @default.
- W135045138 title "Importance of chloride homeostasis in the operation of rhythmic motor networks" @default.
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- W135045138 doi "https://doi.org/10.1016/b978-0-444-53825-3.00006-1" @default.
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