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- W135067300 abstract "Therapy of the patients against African and American trypanosomiasis is based on a few drugs that occasionally cause severe or frequent side effects. Human trypanosomiasis is often a disease for poor people in Africa or Latin America and the market-driven pathways for drug development are not available. Therefore, there is an urgent need to develop new drugs and chemotherapeutic agents especially from natural resources. Monoterpenes, a wide group of natural terpenoids, are found in the essential oils of many dietary plants including fruits, vegetables, and herbs, and are effective in treatment of early or advanced infectious diseases and cancers. Monoterpenes would appear to act through multiple mechanisms in the chemotherapy of trypanosomiasis. These compounds chemically contain various functional groups which can affect via different modes of actions. Among the compounds tested and reported, terpinen-4-ol showed a potent anti-trypanosoma (Trypanosoma brucei) effect with a good selectivity index comparable with trypanocidal drug, suramin. Carvone is another candidate for more anti T. brucei investigations. Monoterpenes bearing aldehyde functional group generally are potent trypanocidal compounds against both Trypanosoma cruzi and T. brucei but need more structural changes for reduction of human cell toxicity. The current review summarizes the present information until 2010 on trypanocidal activities of various classes of monoterpene compounds in order to better design and develop novel drugs with a higher efficacy and lower toxicity." @default.
- W135067300 created "2016-06-24" @default.
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- W135067300 date "2012-01-01" @default.
- W135067300 modified "2023-09-27" @default.
- W135067300 title "Trypanocidal Monoterpenes" @default.
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- W135067300 doi "https://doi.org/10.1016/b978-0-444-59514-0.00006-7" @default.
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