Matches in SemOpenAlex for { <https://semopenalex.org/work/W135333518> ?p ?o ?g. }
- W135333518 endingPage "1193" @default.
- W135333518 startingPage "1186" @default.
- W135333518 abstract "Intrinsic and extrinsic neuromodulation are both thought to be responsible for the flexibility of the neural circuits (central pattern generators) that control rhythmic behaviors. Because the two forms of modulation have been studied in different circuits, it has been difficult to compare them directly. We find that the central pattern generator for biting in Aplysia is modulated both extrinsically and intrinsically. Both forms of modulation increase the frequency of motor programs and shorten the duration of the protraction phase. Extrinsic modulation is mediated by the serotonergic metacerebral cell (MCC) neurons and is mimicked by application of serotonin. Intrinsic modulation is mediated by the cerebral peptide-2 (CP-2) containing CBI-2 interneurons and is mimicked by application of CP-2. Since the effects of CBI-2 and CP-2 occlude each other, the modulatory actions of CBI-2 may be mediated by CP-2 release. Although the effects of intrinsic and extrinsic modulation are similar, the neurons that mediate them are active predominantly at different times, suggesting a specialized role for each system. Metacerebral cell (MCC) activity predominates in the preparatory (appetitive) phase and thus precedes the activation of CBI-2 and biting motor programs. Once the CBI-2s are activated and the biting motor program is initiated, MCC activity declines precipitously. Hence extrinsic modulation prefacilitates biting, whereas intrinsic modulation occurs during biting. Since biting inhibits appetitive behavior, intrinsic modulation cannot be used to prefacilitate biting in the appetitive phase. Thus the sequential use of extrinsic and intrinsic modulation may provide a means for premodulation of biting without the concomitant disruption of appetitive behaviors." @default.
- W135333518 created "2016-06-24" @default.
- W135333518 creator A5016331294 @default.
- W135333518 creator A5017387548 @default.
- W135333518 creator A5022090529 @default.
- W135333518 creator A5074307739 @default.
- W135333518 date "2000-09-01" @default.
- W135333518 modified "2023-10-05" @default.
- W135333518 title "Intrinsic and Extrinsic Modulation of a Single Central Pattern Generating Circuit" @default.
- W135333518 cites W1493165571 @default.
- W135333518 cites W1521440171 @default.
- W135333518 cites W1542613299 @default.
- W135333518 cites W1555091596 @default.
- W135333518 cites W1568775195 @default.
- W135333518 cites W1583914347 @default.
- W135333518 cites W1642252169 @default.
- W135333518 cites W1642710185 @default.
- W135333518 cites W1818452701 @default.
- W135333518 cites W1824021067 @default.
- W135333518 cites W1874945652 @default.
- W135333518 cites W1944706957 @default.
- W135333518 cites W1963656947 @default.
- W135333518 cites W1963707980 @default.
- W135333518 cites W1966688216 @default.
- W135333518 cites W1971266177 @default.
- W135333518 cites W1980149369 @default.
- W135333518 cites W1990309400 @default.
- W135333518 cites W1994198171 @default.
- W135333518 cites W1998477001 @default.
- W135333518 cites W2000596633 @default.
- W135333518 cites W2002775981 @default.
- W135333518 cites W2006864757 @default.
- W135333518 cites W2006947905 @default.
- W135333518 cites W2007931217 @default.
- W135333518 cites W2014590358 @default.
- W135333518 cites W2017708908 @default.
- W135333518 cites W2025140960 @default.
- W135333518 cites W2043956439 @default.
- W135333518 cites W2046489983 @default.
- W135333518 cites W2048545032 @default.
- W135333518 cites W2060995001 @default.
- W135333518 cites W2064168483 @default.
- W135333518 cites W2077777980 @default.
- W135333518 cites W2078926357 @default.
- W135333518 cites W2082189201 @default.
- W135333518 cites W2084325190 @default.
- W135333518 cites W2093469113 @default.
- W135333518 cites W2141704625 @default.
- W135333518 cites W2142444973 @default.
- W135333518 cites W2143624690 @default.
- W135333518 cites W2164796107 @default.
- W135333518 cites W2182554754 @default.
- W135333518 cites W2212274541 @default.
- W135333518 cites W2219028196 @default.
- W135333518 cites W2253198671 @default.
- W135333518 cites W2276360330 @default.
- W135333518 cites W2289524359 @default.
- W135333518 cites W2323016396 @default.
- W135333518 cites W2323397761 @default.
- W135333518 cites W2407159192 @default.
- W135333518 cites W2416683863 @default.
- W135333518 cites W4321429424 @default.
- W135333518 doi "https://doi.org/10.1152/jn.2000.84.3.1186" @default.
- W135333518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10979994" @default.
- W135333518 hasPublicationYear "2000" @default.
- W135333518 type Work @default.
- W135333518 sameAs 135333518 @default.
- W135333518 citedByCount "76" @default.
- W135333518 countsByYear W1353335182012 @default.
- W135333518 countsByYear W1353335182013 @default.
- W135333518 countsByYear W1353335182014 @default.
- W135333518 countsByYear W1353335182015 @default.
- W135333518 countsByYear W1353335182016 @default.
- W135333518 countsByYear W1353335182017 @default.
- W135333518 countsByYear W1353335182018 @default.
- W135333518 countsByYear W1353335182019 @default.
- W135333518 countsByYear W1353335182020 @default.
- W135333518 countsByYear W1353335182021 @default.
- W135333518 crossrefType "journal-article" @default.
- W135333518 hasAuthorship W135333518A5016331294 @default.
- W135333518 hasAuthorship W135333518A5017387548 @default.
- W135333518 hasAuthorship W135333518A5022090529 @default.
- W135333518 hasAuthorship W135333518A5074307739 @default.
- W135333518 hasConcept C121332964 @default.
- W135333518 hasConcept C123079801 @default.
- W135333518 hasConcept C126322002 @default.
- W135333518 hasConcept C135343436 @default.
- W135333518 hasConcept C15744967 @default.
- W135333518 hasConcept C169453685 @default.
- W135333518 hasConcept C169760540 @default.
- W135333518 hasConcept C170493617 @default.
- W135333518 hasConcept C185592680 @default.
- W135333518 hasConcept C18903297 @default.
- W135333518 hasConcept C24890656 @default.
- W135333518 hasConcept C2775864247 @default.
- W135333518 hasConcept C2776039942 @default.
- W135333518 hasConcept C2778178740 @default.
- W135333518 hasConcept C2780375056 @default.