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- W135392341 abstract "OBJECTIVE The stability of ketamine in biological samples was studied under different storage temperature and time. METHODS The rabbits were given intragastric administration of ketamine with a dose of 150 mg/kg and were sacrificed after 30 minutes. Blood, liver, kidney and brain of the rabbits were stored at room temperature (between 18 degrees C and 24 degrees C) and -20 degrees C. The specimens were analyzed at different times by GC-MS and GC-NPD. RESULTS At -20 degrees C, the concentration of ketamine decreased in all of samples (P < 0.05) within 30 days. The concentration of ketamine increased in all of samples stored at room temperature after 5 days(P < 0.05). CONCLUSION The stability of ketamine in biological samples stored at -20 degrees C was better than that at room temperature. The samples suspected containing ketamine should be stored at -20 degrees C and should be tested as soon as possible." @default.
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- W135392341 date "2009-12-01" @default.
- W135392341 modified "2023-10-13" @default.
- W135392341 title "Effect of temperature and time on stability of ketamine in biological samples" @default.
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