Matches in SemOpenAlex for { <https://semopenalex.org/work/W135482192> ?p ?o ?g. }
- W135482192 endingPage "419" @default.
- W135482192 startingPage "411" @default.
- W135482192 abstract "The antiviral drugs against the human herpes viruses provided pioneering insights, which have led to the development of the fi eld of antiviral therapy. The fi rst successful use of antiviral drugs to treat any life-threatening viral infection was Vidarabine (adenosine arabnoside) in 1977 (1). This was followed by the development of Acyclovir as the fi rst specifi c antiviral drug which required a viral enzyme (thymidine kinase, TK) for activation to a nucleoside triphosphate, which inhibited the viral DNA polymerase and was a chain-terminator of viral DNA elongation (2, 3). When tested against clinical viral isolates, acyclovir was most effective against those herpes viruses which established latency in neuronal tissue (HSV-1, HSV-2, VZV) (4), with some activity against EBV, and very little against clinical isolates of CMV in a plaque reduction assay (4, 5). With the possible exception of infl uenza A virus and amantadine, this marked the beginnings of antiviral therapy." @default.
- W135482192 created "2016-06-24" @default.
- W135482192 creator A5082691948 @default.
- W135482192 date "2009-01-01" @default.
- W135482192 modified "2023-09-27" @default.
- W135482192 title "Mechanisms of Resistance of Antiviral Drugs Active Against the Human Herpes Viruses" @default.
- W135482192 cites W1563147703 @default.
- W135482192 cites W1593382835 @default.
- W135482192 cites W1602988273 @default.
- W135482192 cites W1625770513 @default.
- W135482192 cites W1634217411 @default.
- W135482192 cites W1670236664 @default.
- W135482192 cites W1802007569 @default.
- W135482192 cites W1934602117 @default.
- W135482192 cites W1939536163 @default.
- W135482192 cites W1964359729 @default.
- W135482192 cites W1980464074 @default.
- W135482192 cites W1995748931 @default.
- W135482192 cites W2019678244 @default.
- W135482192 cites W2026396393 @default.
- W135482192 cites W2031610597 @default.
- W135482192 cites W2033028600 @default.
- W135482192 cites W2041743557 @default.
- W135482192 cites W2042370689 @default.
- W135482192 cites W2045360603 @default.
- W135482192 cites W2046212163 @default.
- W135482192 cites W2047415999 @default.
- W135482192 cites W2051268926 @default.
- W135482192 cites W2052460032 @default.
- W135482192 cites W2055397341 @default.
- W135482192 cites W2063466305 @default.
- W135482192 cites W2071147879 @default.
- W135482192 cites W2081935386 @default.
- W135482192 cites W2089824168 @default.
- W135482192 cites W2090108157 @default.
- W135482192 cites W2090997741 @default.
- W135482192 cites W2096682430 @default.
- W135482192 cites W2097458512 @default.
- W135482192 cites W2104796719 @default.
- W135482192 cites W2105881499 @default.
- W135482192 cites W2111770560 @default.
- W135482192 cites W2114786252 @default.
- W135482192 cites W2116825794 @default.
- W135482192 cites W2124758522 @default.
- W135482192 cites W2131604090 @default.
- W135482192 cites W2133520611 @default.
- W135482192 cites W2143002593 @default.
- W135482192 cites W2152264576 @default.
- W135482192 cites W2153044520 @default.
- W135482192 cites W2160661342 @default.
- W135482192 cites W2160993726 @default.
- W135482192 cites W2164889663 @default.
- W135482192 cites W2170540805 @default.
- W135482192 cites W2170768004 @default.
- W135482192 cites W2288634103 @default.
- W135482192 cites W2333553600 @default.
- W135482192 cites W254776376 @default.
- W135482192 cites W4231383028 @default.
- W135482192 doi "https://doi.org/10.1007/978-1-59745-180-2_30" @default.
- W135482192 hasPublicationYear "2009" @default.
- W135482192 type Work @default.
- W135482192 sameAs 135482192 @default.
- W135482192 citedByCount "0" @default.
- W135482192 crossrefType "book-chapter" @default.
- W135482192 hasAuthorship W135482192A5082691948 @default.
- W135482192 hasConcept C140704245 @default.
- W135482192 hasConcept C159047783 @default.
- W135482192 hasConcept C2522874641 @default.
- W135482192 hasConcept C2776147627 @default.
- W135482192 hasConcept C2776409557 @default.
- W135482192 hasConcept C2776543447 @default.
- W135482192 hasConcept C2776694085 @default.
- W135482192 hasConcept C2776723293 @default.
- W135482192 hasConcept C2776755627 @default.
- W135482192 hasConcept C2777333352 @default.
- W135482192 hasConcept C2777374534 @default.
- W135482192 hasConcept C2778779478 @default.
- W135482192 hasConcept C2779263901 @default.
- W135482192 hasConcept C2779450786 @default.
- W135482192 hasConcept C2779756493 @default.
- W135482192 hasConcept C2780727368 @default.
- W135482192 hasConcept C2781196997 @default.
- W135482192 hasConcept C2993512173 @default.
- W135482192 hasConcept C3020491458 @default.
- W135482192 hasConcept C54355233 @default.
- W135482192 hasConcept C55493867 @default.
- W135482192 hasConcept C86803240 @default.
- W135482192 hasConceptScore W135482192C140704245 @default.
- W135482192 hasConceptScore W135482192C159047783 @default.
- W135482192 hasConceptScore W135482192C2522874641 @default.
- W135482192 hasConceptScore W135482192C2776147627 @default.
- W135482192 hasConceptScore W135482192C2776409557 @default.
- W135482192 hasConceptScore W135482192C2776543447 @default.
- W135482192 hasConceptScore W135482192C2776694085 @default.
- W135482192 hasConceptScore W135482192C2776723293 @default.
- W135482192 hasConceptScore W135482192C2776755627 @default.
- W135482192 hasConceptScore W135482192C2777333352 @default.
- W135482192 hasConceptScore W135482192C2777374534 @default.