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• W13558574 abstract "Publisher Summary This chapter describes unique gamete characteristics that determine which approaches can be used to study them, and discusses systems that are particularly good for the genetic analysis of fertilization.. In the past, genetic approaches to a molecular understanding of fertilization have often been overlooked. However, advances in genome sequencing, linkage maps, and targeted gene disruption methods have opened many more species to serious genetic dissection. At the time of fertilization, the oocytes of almost all vertebrates are arrested in some stage of meiosis. The relationship of meiosis to fertilization in invertebrates' oocytes, however, is much more variable with oocytes of various species being fertilized in the germinal vesicle stage during meiosis or after the completion of meiosis. Oocytes have a very robust translational system that has been used to determine whether specific signal transduction pathways are functional. mRNA specifying a receptor of interest can be injected into oocytes. The approach involving injection of mRNA specified receptor into oocytes has been used in many species. In mammalian fertilization, sperm mitochondria are incorporated into the oocyte, yet only maternal mitochondria are inherited by the zygote. Specific mitochondrial proteins are ubiquinated in the spermatid. Sperm mitochondria are destroyed in the oocyte by ubiquitin-stimulated proteolysis. This chapter further looks into spermatozoa and genetic model systems regarding species like Yeast, Chlamydomonas , Caenorhabditis Elegans , Drosophila , Zebrafish ( Danio Rerio ), and Mouse ." @default.
• W13558574 created "2016-06-24" @default.
• W13558574 creator A5001616640 @default.
• W13558574 creator A5050641358 @default.
• W13558574 date "2002-01-01" @default.
• W13558574 modified "2023-09-27" @default.
• W13558574 title "Molecular Genetics of Fertilization" @default.
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• W13558574 doi "https://doi.org/10.1016/b978-012311629-1/50013-9" @default.
• W13558574 hasPublicationYear "2002" @default.
• W13558574 type Work @default.
• W13558574 sameAs 13558574 @default.

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