Matches in SemOpenAlex for { <https://semopenalex.org/work/W13560170> ?p ?o ?g. }
- W13560170 endingPage "2" @default.
- W13560170 startingPage "770" @default.
- W13560170 abstract "Beyond their role in haemostasis, platelets can actively contribute to immunity. The activation of the platelet collagen receptor glycoprotein VI (GPVI) promotes the release of small extracellular vesicles called microparticles. These microparticles are found in the joint bathing fluid of patients with rheumatoid arthritis (RA) and are thought to amplify inflammation. The gene coding for GPVI is localised on chromosome 19q13.4 and contains different single nucleotide polymorphisms (SNPs). Five non-synonymous SNPs define the major and minor haplotypes of GPVI. The minor haplotype is associated with higher risk of cardiovascular incidents. In this study, we examined whether this minor haplotype is also associated with RA.Allelic discrimination of the SNPs reported to define these haplotypes encoding SKTQH and PEALN protein isoforms, ie rs1613662, rs1654416, rs2304167, rs1654413 and rs1671152, was performed in 399 RA patients and their two parents, all of Western European ethnicity. Statistical analysis relied on the transmission disequilibrium test by the use of the FBAT programme. Haplotypes were also estimated by the FBAT programme.We observed no statistically significant transmission disequilibrium for the SNPs tested. The major haplotype TAAC, which encodes the SKTQH isoform, was identified in 78% of our cohort individuals, and the CGGA haplotype which encodes the PEALN isoform was identified in 8% of our individuals. We observed no association of these haplotypes of the GPVI gene with RA.This demonstrates that the SNPs tested within the GPVI gene are not associated with RA susceptibility and/or severity, suggesting that platelet GPVI may contribute to arthritis independently of its gene polymorphism." @default.
- W13560170 created "2016-06-24" @default.
- W13560170 creator A5001646568 @default.
- W13560170 creator A5006123817 @default.
- W13560170 creator A5008108487 @default.
- W13560170 creator A5024513740 @default.
- W13560170 creator A5026614224 @default.
- W13560170 creator A5033647623 @default.
- W13560170 creator A5038309467 @default.
- W13560170 creator A5042606678 @default.
- W13560170 creator A5046171667 @default.
- W13560170 creator A5049731235 @default.
- W13560170 creator A5054608926 @default.
- W13560170 creator A5081629453 @default.
- W13560170 creator A5088484079 @default.
- W13560170 date "2013-06-07" @default.
- W13560170 modified "2023-10-18" @default.
- W13560170 title "Association study of the platelet collagen receptor glycoprotein VI gene with rheumatoid arthritis." @default.
- W13560170 cites W1808018531 @default.
- W13560170 cites W1973528660 @default.
- W13560170 cites W1977945634 @default.
- W13560170 cites W1999254278 @default.
- W13560170 cites W2010024991 @default.
- W13560170 cites W2022631529 @default.
- W13560170 cites W2058217708 @default.
- W13560170 cites W2086736448 @default.
- W13560170 cites W2111363398 @default.
- W13560170 cites W2115783720 @default.
- W13560170 cites W2122803817 @default.
- W13560170 cites W2124848590 @default.
- W13560170 cites W2134783591 @default.
- W13560170 cites W2140418233 @default.
- W13560170 cites W2152348310 @default.
- W13560170 cites W2158850359 @default.
- W13560170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23739280" @default.
- W13560170 hasPublicationYear "2013" @default.
- W13560170 type Work @default.
- W13560170 sameAs 13560170 @default.
- W13560170 citedByCount "1" @default.
- W13560170 countsByYear W135601702018 @default.
- W13560170 crossrefType "journal-article" @default.
- W13560170 hasAuthorship W13560170A5001646568 @default.
- W13560170 hasAuthorship W13560170A5006123817 @default.
- W13560170 hasAuthorship W13560170A5008108487 @default.
- W13560170 hasAuthorship W13560170A5024513740 @default.
- W13560170 hasAuthorship W13560170A5026614224 @default.
- W13560170 hasAuthorship W13560170A5033647623 @default.
- W13560170 hasAuthorship W13560170A5038309467 @default.
- W13560170 hasAuthorship W13560170A5042606678 @default.
- W13560170 hasAuthorship W13560170A5046171667 @default.
- W13560170 hasAuthorship W13560170A5049731235 @default.
- W13560170 hasAuthorship W13560170A5054608926 @default.
- W13560170 hasAuthorship W13560170A5081629453 @default.
- W13560170 hasAuthorship W13560170A5088484079 @default.
- W13560170 hasConcept C104317684 @default.
- W13560170 hasConcept C135763542 @default.
- W13560170 hasConcept C153209595 @default.
- W13560170 hasConcept C157410074 @default.
- W13560170 hasConcept C180754005 @default.
- W13560170 hasConcept C197754878 @default.
- W13560170 hasConcept C203014093 @default.
- W13560170 hasConcept C26828662 @default.
- W13560170 hasConcept C2780573682 @default.
- W13560170 hasConcept C35605836 @default.
- W13560170 hasConcept C54355233 @default.
- W13560170 hasConcept C71924100 @default.
- W13560170 hasConcept C86803240 @default.
- W13560170 hasConcept C89560881 @default.
- W13560170 hasConceptScore W13560170C104317684 @default.
- W13560170 hasConceptScore W13560170C135763542 @default.
- W13560170 hasConceptScore W13560170C153209595 @default.
- W13560170 hasConceptScore W13560170C157410074 @default.
- W13560170 hasConceptScore W13560170C180754005 @default.
- W13560170 hasConceptScore W13560170C197754878 @default.
- W13560170 hasConceptScore W13560170C203014093 @default.
- W13560170 hasConceptScore W13560170C26828662 @default.
- W13560170 hasConceptScore W13560170C2780573682 @default.
- W13560170 hasConceptScore W13560170C35605836 @default.
- W13560170 hasConceptScore W13560170C54355233 @default.
- W13560170 hasConceptScore W13560170C71924100 @default.
- W13560170 hasConceptScore W13560170C86803240 @default.
- W13560170 hasConceptScore W13560170C89560881 @default.
- W13560170 hasIssue "5" @default.
- W13560170 hasLocation W135601701 @default.
- W13560170 hasLocation W135601702 @default.
- W13560170 hasOpenAccess W13560170 @default.
- W13560170 hasPrimaryLocation W135601701 @default.
- W13560170 hasRelatedWork W1551477413 @default.
- W13560170 hasRelatedWork W1966708416 @default.
- W13560170 hasRelatedWork W2019989714 @default.
- W13560170 hasRelatedWork W2050501127 @default.
- W13560170 hasRelatedWork W2050778956 @default.
- W13560170 hasRelatedWork W2068033436 @default.
- W13560170 hasRelatedWork W2081569445 @default.
- W13560170 hasRelatedWork W2154453877 @default.
- W13560170 hasRelatedWork W2410452464 @default.
- W13560170 hasRelatedWork W4285586820 @default.
- W13560170 hasVolume "31" @default.