FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W13568861> ?p ?o ?g. }

• W13568861 abstract "Several studies revealed that MSC from human bone marrow can downregulate graft-versus-host disease (GVHD) after allogeneic HSCT.Herein we present 50 patients with acute GVHD who got 74 (1-4) MSC infusions for 54 separate episodes of aGVHD.aGVHD was defined as steroid resistant grade IV aGVHD in 42 cases. The major presentation was gastrointestinal GVHD; two (n=18) or more (n=21) systems were involved in the majority of cases. The 1(st) infusion with MSC was given on day +27 (range, 1 to 136); d+45 (range, +11 to +150) post diagnosis of aGVHD and HSCT, respectively. In 2/3 of the cases treatment was performed with frozen stocked MSCs; in 62 cases early passages (1-3) were used. The median number of infused cells was 1.14±0.47 million per kg in the first injection and up to 4.27 (1.70±1.10) millions in total. The two patients with aggressive liver GVHD received MSCs injections intra hepatic arteries without changes of blood flow or evidence cytolysis, but also without a visible effect. Disease free survival at 3.6 years was 56%. We observed better overall survival in patients with GVHD grade < 4, in responders to the 1(st) treatment with MSC, and in pediatric group. The multivariate analysis demonstrated independent influence on survival of initial response and younger age. There were no immediate or late toxicity or side effects.Injection of MSCs seems to be a promising and safe treatment of GVHD. The encouraging results obviously should be confirmed in a randomized prospective study." @default.
• W13568861 created "2016-06-24" @default.
• W13568861 creator A5008461035 @default.
• W13568861 creator A5011080782 @default.
• W13568861 creator A5011180142 @default.
• W13568861 creator A5011851578 @default.
• W13568861 creator A5013991113 @default.
• W13568861 creator A5019096874 @default.
• W13568861 creator A5020301140 @default.
• W13568861 creator A5026533997 @default.
• W13568861 creator A5030282008 @default.
• W13568861 creator A5044249462 @default.
• W13568861 creator A5058925624 @default.
• W13568861 creator A5068248201 @default.
• W13568861 creator A5070168648 @default.
• W13568861 creator A5081214298 @default.
• W13568861 creator A5085701502 @default.
• W13568861 date "2013-01-01" @default.
• W13568861 modified "2023-10-04" @default.
• W13568861 title "Treatment of severe steroid resistant acute GVHD with mesenchymal stromal cells (MSC)." @default.
• W13568861 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3755522" @default.
• W13568861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23997985" @default.
• W13568861 hasPublicationYear "2013" @default.
• W13568861 type Work @default.
• W13568861 sameAs 13568861 @default.
• W13568861 citedByCount "53" @default.
• W13568861 countsByYear W135688612012 @default.
• W13568861 countsByYear W135688612014 @default.
• W13568861 countsByYear W135688612015 @default.
• W13568861 countsByYear W135688612016 @default.
• W13568861 countsByYear W135688612017 @default.
• W13568861 countsByYear W135688612018 @default.
• W13568861 countsByYear W135688612019 @default.
• W13568861 countsByYear W135688612020 @default.
• W13568861 countsByYear W135688612021 @default.
• W13568861 countsByYear W135688612022 @default.
• W13568861 countsByYear W135688612023 @default.
• W13568861 crossrefType "journal-article" @default.
• W13568861 hasAuthorship W13568861A5008461035 @default.
• W13568861 hasAuthorship W13568861A5011080782 @default.
• W13568861 hasAuthorship W13568861A5011180142 @default.
• W13568861 hasAuthorship W13568861A5011851578 @default.
• W13568861 hasAuthorship W13568861A5013991113 @default.
• W13568861 hasAuthorship W13568861A5019096874 @default.
• W13568861 hasAuthorship W13568861A5020301140 @default.
• W13568861 hasAuthorship W13568861A5026533997 @default.
• W13568861 hasAuthorship W13568861A5030282008 @default.
• W13568861 hasAuthorship W13568861A5044249462 @default.
• W13568861 hasAuthorship W13568861A5058925624 @default.
• W13568861 hasAuthorship W13568861A5068248201 @default.
• W13568861 hasAuthorship W13568861A5070168648 @default.
• W13568861 hasAuthorship W13568861A5081214298 @default.
• W13568861 hasAuthorship W13568861A5085701502 @default.
• W13568861 hasConcept C126322002 @default.
• W13568861 hasConcept C141071460 @default.
• W13568861 hasConcept C142724271 @default.
• W13568861 hasConcept C16930146 @default.
• W13568861 hasConcept C198826908 @default.
• W13568861 hasConcept C2779134260 @default.
• W13568861 hasConcept C2779972918 @default.
• W13568861 hasConcept C2780007613 @default.
• W13568861 hasConcept C29730261 @default.
• W13568861 hasConcept C71924100 @default.
• W13568861 hasConcept C90924648 @default.
• W13568861 hasConceptScore W13568861C126322002 @default.
• W13568861 hasConceptScore W13568861C141071460 @default.
• W13568861 hasConceptScore W13568861C142724271 @default.
• W13568861 hasConceptScore W13568861C16930146 @default.
• W13568861 hasConceptScore W13568861C198826908 @default.
• W13568861 hasConceptScore W13568861C2779134260 @default.
• W13568861 hasConceptScore W13568861C2779972918 @default.
• W13568861 hasConceptScore W13568861C2780007613 @default.
• W13568861 hasConceptScore W13568861C29730261 @default.
• W13568861 hasConceptScore W13568861C71924100 @default.
• W13568861 hasConceptScore W13568861C90924648 @default.
• W13568861 hasLocation W135688611 @default.
• W13568861 hasOpenAccess W13568861 @default.
• W13568861 hasPrimaryLocation W135688611 @default.
• W13568861 hasRelatedWork W1944600343 @default.
• W13568861 hasRelatedWork W1982408656 @default.
• W13568861 hasRelatedWork W1988489929 @default.
• W13568861 hasRelatedWork W1999670686 @default.
• W13568861 hasRelatedWork W2007536176 @default.
• W13568861 hasRelatedWork W2009045750 @default.
• W13568861 hasRelatedWork W2012132345 @default.
• W13568861 hasRelatedWork W2012302358 @default.
• W13568861 hasRelatedWork W2013107151 @default.
• W13568861 hasRelatedWork W2025371271 @default.
• W13568861 hasRelatedWork W2033230449 @default.
• W13568861 hasRelatedWork W2033284503 @default.
• W13568861 hasRelatedWork W2041864288 @default.
• W13568861 hasRelatedWork W2058473775 @default.
• W13568861 hasRelatedWork W2092929403 @default.
• W13568861 hasRelatedWork W2102330961 @default.
• W13568861 hasRelatedWork W2114998726 @default.
• W13568861 hasRelatedWork W2138946470 @default.
• W13568861 hasRelatedWork W2143258371 @default.
• W13568861 hasRelatedWork W2145512995 @default.
• W13568861 isParatext "false" @default.
• W13568861 isRetracted "false" @default.

• next