Matches in SemOpenAlex for { <https://semopenalex.org/work/W135877420> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W135877420 endingPage "29" @default.
- W135877420 startingPage "511" @default.
- W135877420 abstract "Four mouse hybridomas secreting monoclonal immunoglobulin G (IgG) antibodies to epidermal growth factor (EGF) receptors of A431 cells were obtained independently from four fusion experiments. Three of the antibodies, 528 IgG, 225 IgG, and 579 IgG, inhibited the binding of [125I]EGF to A431 cells by at least 95%, and they competed with each other for binding to A431 cells. These antibodies bound to A431 cells, HeLa-S cells and human foreskin fibroblasts with dissociation constants in the range of Kd = 0.6 X 10(-9) to 2.5 X 10(-9) M. The fourth monoclonal antibody, 455 IgG, bound to A431 cells with lower affinity (Kd = 2.0 X 10(-8) M), and it had no effect on the binding of either EGF or the other antibodies to A431 cells. All four antibodies immunoprecipitated EGF receptors from Triton X-100 extracts of A431 membranes, but they were unable to bind to three rodent cell lines. In biological assays, none of the antibodies was able to mimic EGF. The antibodies which inhibited the binding of EGF blocked EGF-enhanced phosphorylation of A431 membrane proteins and inhibited EGF induced human fibroblast proliferation. These three antagonistic antibodies also partially reversed the inhibition of A431 growth by EGF. In contrast, 455 IgG had no effect on the early or delayed cellular responses to EGF." @default.
- W135877420 created "2016-06-24" @default.
- W135877420 creator A5006504847 @default.
- W135877420 creator A5008515664 @default.
- W135877420 creator A5043787919 @default.
- W135877420 creator A5052139559 @default.
- W135877420 creator A5054925416 @default.
- W135877420 creator A5066905633 @default.
- W135877420 date "1983-12-01" @default.
- W135877420 modified "2023-09-23" @default.
- W135877420 title "Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors." @default.
- W135877420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6094961" @default.
- W135877420 hasPublicationYear "1983" @default.
- W135877420 type Work @default.
- W135877420 sameAs 135877420 @default.
- W135877420 citedByCount "176" @default.
- W135877420 countsByYear W1358774202012 @default.
- W135877420 countsByYear W1358774202013 @default.
- W135877420 countsByYear W1358774202014 @default.
- W135877420 countsByYear W1358774202015 @default.
- W135877420 countsByYear W1358774202016 @default.
- W135877420 countsByYear W1358774202017 @default.
- W135877420 countsByYear W1358774202018 @default.
- W135877420 countsByYear W1358774202019 @default.
- W135877420 countsByYear W1358774202020 @default.
- W135877420 countsByYear W1358774202021 @default.
- W135877420 countsByYear W1358774202023 @default.
- W135877420 crossrefType "journal-article" @default.
- W135877420 hasAuthorship W135877420A5006504847 @default.
- W135877420 hasAuthorship W135877420A5008515664 @default.
- W135877420 hasAuthorship W135877420A5043787919 @default.
- W135877420 hasAuthorship W135877420A5052139559 @default.
- W135877420 hasAuthorship W135877420A5054925416 @default.
- W135877420 hasAuthorship W135877420A5066905633 @default.
- W135877420 hasConcept C1491633281 @default.
- W135877420 hasConcept C153911025 @default.
- W135877420 hasConcept C159654299 @default.
- W135877420 hasConcept C170493617 @default.
- W135877420 hasConcept C197462201 @default.
- W135877420 hasConcept C203014093 @default.
- W135877420 hasConcept C2776362946 @default.
- W135877420 hasConcept C2777546739 @default.
- W135877420 hasConcept C29537977 @default.
- W135877420 hasConcept C2994460389 @default.
- W135877420 hasConcept C47170353 @default.
- W135877420 hasConcept C542903549 @default.
- W135877420 hasConcept C54355233 @default.
- W135877420 hasConcept C55493867 @default.
- W135877420 hasConcept C67082663 @default.
- W135877420 hasConcept C81885089 @default.
- W135877420 hasConcept C86803240 @default.
- W135877420 hasConceptScore W135877420C1491633281 @default.
- W135877420 hasConceptScore W135877420C153911025 @default.
- W135877420 hasConceptScore W135877420C159654299 @default.
- W135877420 hasConceptScore W135877420C170493617 @default.
- W135877420 hasConceptScore W135877420C197462201 @default.
- W135877420 hasConceptScore W135877420C203014093 @default.
- W135877420 hasConceptScore W135877420C2776362946 @default.
- W135877420 hasConceptScore W135877420C2777546739 @default.
- W135877420 hasConceptScore W135877420C29537977 @default.
- W135877420 hasConceptScore W135877420C2994460389 @default.
- W135877420 hasConceptScore W135877420C47170353 @default.
- W135877420 hasConceptScore W135877420C542903549 @default.
- W135877420 hasConceptScore W135877420C54355233 @default.
- W135877420 hasConceptScore W135877420C55493867 @default.
- W135877420 hasConceptScore W135877420C67082663 @default.
- W135877420 hasConceptScore W135877420C81885089 @default.
- W135877420 hasConceptScore W135877420C86803240 @default.
- W135877420 hasIssue "5" @default.
- W135877420 hasLocation W1358774201 @default.
- W135877420 hasOpenAccess W135877420 @default.
- W135877420 hasPrimaryLocation W1358774201 @default.
- W135877420 hasRelatedWork W1472721622 @default.
- W135877420 hasRelatedWork W1497356015 @default.
- W135877420 hasRelatedWork W1517530468 @default.
- W135877420 hasRelatedWork W1973071934 @default.
- W135877420 hasRelatedWork W1976002101 @default.
- W135877420 hasRelatedWork W2063581177 @default.
- W135877420 hasRelatedWork W2070449452 @default.
- W135877420 hasRelatedWork W2093951180 @default.
- W135877420 hasRelatedWork W2142714117 @default.
- W135877420 hasRelatedWork W975765317 @default.
- W135877420 hasVolume "1" @default.
- W135877420 isParatext "false" @default.
- W135877420 isRetracted "false" @default.
- W135877420 magId "135877420" @default.
- W135877420 workType "article" @default.