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- W135894611 abstract "This chapter reviews the role of antioxidants in senescence and wasting. The hallmarks of senescence as well as wasting include the massive loss of body cell mass (bcm) and muscle function, decreased resistance to infections, frailty (increased probability of disability), and organ failure. Wasting is a common phenomenon in malignancies, sepsis, trauma, and certain infectious diseases, including HIV infection. In the treatment of cancer patients, wasting is often a limiting factor that prevents the application of aggressive chemotherapy. In old age, the loss of skeletal muscle mass is associated with a compromised physical and social function. An increasingly popular hypothesis states that senescence may result from the accumulation of oxidative damage and that dietary antioxidants may slow the degenerative process. In line with this hypothesis, vitamin E is shown to ameliorate age-related health problems, and certain age-related degenerative processes are even found to be reversed by treatment with antioxidants." @default.
- W135894611 created "2016-06-24" @default.
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- W135894611 date "2000-01-01" @default.
- W135894611 modified "2023-09-24" @default.
- W135894611 title "Antioxidants in Senescence and Wasting" @default.
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- W135894611 doi "https://doi.org/10.1016/b978-012636670-9/50026-x" @default.
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