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- W136134437 abstract "Synaptic junctions, including γ-aminobutyric acid (GABA)-gated CI− channels (GABAA receptors), are expressed in almost every brain neuron. In the neocortex, they are expressed in apical dendrites, somata, and initial axon segments of pyramidal neurons in which GABAA receptors play an important role in synchronizing rhythmic columnary activity and other firing patterns that subserve integrative processes of cortical functions. The intrinsic activity of GABA-gating at GABAA receptors depends on the structure of the subunits assembled in these pentameric channels (for a review see MacDonald and Olsen 1994; Costa and Guidotti 1996; Costa 1998), and on the expression of recognition sites for endogenous molecules (endozepines and neurosteroids), which modulate GABA-gated Cl−-current intensity (Costa and Guidotti 1991; Guidotti and Costa 1998; Matsumoto et al. 1999)." @default.
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- W136134437 date "2001-01-01" @default.
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- W136134437 title "Tolerance and Dependence to Ligands of the Benzodiazepine Recognition Sites Expressed by GABAA Receptors" @default.
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